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Category: evolution – Page 27

Molecular motors put significant twists to DNA loops

Astrocytes are star-shaped glial cells in the central nervous system that support neuronal function, maintain the blood-brain barrier, and contribute to brain repair and homeostasis. The evolution of these cells throughout the progression of Alzheimer’s disease (AD) is still poorly understood, particularly when compared to that of neurons and other cell types.

Researchers at Massachusetts General Hospital, the Massachusetts Alzheimer’s Disease Research Center, Harvard Medical School and Abbvie Inc. set out to fill this gap in the literature.

Their paper, published in Nature Neuroscience, provides one of the most detailed accounts to date of how different astrocyte subclusters respond to AD across different brain regions and disease stages, providing valuable insights into the cellular dynamics of the disease.

A New Era in Amphibian Biology: Scientists Use Viruses To Study Frog Nervous System Development

Researchers have developed a method using viruses to track neuronal development in frogs, shedding light on the evolution of vertebrate nervous systems and offering comparative insights with mammals.

Although viruses are typically associated with illnesses, not all viruses are harmful or cause disease. Some are instrumental in therapeutic treatments and vaccinations. In scientific research, viruses are often used to infect certain cells, genetically modify them, or visualize neurons in the organism’s central nervous system (CNS)—the command center made up of the brain, spinal cord, and nerves.

The highlighting process has now been successfully applied to amphibians, which are crucial for understanding the brain and spinal cord of tetrapods—four-limbed animals, including humans. This has been shown in a new study by an international EDGE consortium jointly led by the Sweeney Lab at the Institute of Science and Technology Austria (ISTA) and the Tosches Lab at Columbia University.

Rewriting Evolution: Study Shows Neanderthals and Humans Were Not the Same Species

A study suggests that by the time H. sapiens expanded, the differentiation between the two species had progressed to the extent that they were distinct and recognizable as separate species.

A recent study conducted by researchers from London’s Natural History Museum and the Institute of Philosophy at KU Leuven has strengthened the argument that Neanderthals and modern humans (Homo sapiens) should be classified as distinct species to more accurately trace our evolutionary history.

Different researchers have different definitions as to what classifies as a species. It is undisputed that H. sapiens and Neanderthals originate from the same parental species, however studies into Neanderthal genetics and evolution have reignited the debate over whether they should be classed as separate from H. sapiens or rather a subspecies (H. sapiens neanderthalensis).

New insights into the evolution and paleoecology of mosasaurs

Mosasaurs are extinct marine lizards, spectacular examples of which were first discovered in 1766 near Maastricht in the Netherlands, fueling the rise of the field of vertebrate paleontology. Paleontologist Michael Polcyn presented the most comprehensive study to date on the early evolution and ecology of these extinct marine reptiles.

On 16 December, Polcyn will receive his Ph.D. from Utrecht University for his research into the evolution of the mosasaurs. Mosasaurs are a textbook example of macroevolution, the emergence of new and distinct groups of animals, above the level of species. Although they have been studied for centuries, new discoveries, novel research approaches, and the application of technology, are still teaching us about their relationships and behaviors, some of which continue to surprise us.

For example, through the use of detailed comparative anatomy aided by micro-CT scanning technology, we have gained a much better understanding of what group of lizards mosasaurs likely evolved from.

Eyes on the sun: Naked thallium-205 ion decay reveals history over millions of years

The sun, the essential engine that sustains life on Earth, generates its tremendous energy through the process of nuclear fusion. At the same time, it releases a continuous stream of neutrinos—particles that serve as messengers of its internal dynamics. Although modern neutrino detectors unveil the sun’s present behavior, significant questions linger about its stability over periods of millions of years—a timeframe that spans human evolution and significant climate changes.

Finding answers to this is the goal of the LORandite EXperiment (LOREX) that requires a precise knowledge of the solar neutrino cross section on thallium. This information has now been provided by an international collaboration of scientists using the unique facilities at GSI/FAIR’s Experimental Storage Ring ESR in Darmstadt to obtain an essential measurement that will help to understand the long-term stability of the sun. The results of the measurements have been published in the journal Physical Review Letters.

LOREX is the only long-time geochemical solar neutrino experiment still actively pursued. Proposed in the 1980s, it aims to measure solar neutrino flux averaged over a remarkable four million years, corresponding to the geological age of the lorandite ore.

Forget Black Holes — White Holes Would Break Your Puny Brain

Black holes have long fascinated scientists, known for their ability to trap anything that crosses their event horizon. But what if there were a counterpart to black holes? Enter the white hole—a theoretical singularity where nothing can enter, but energy and matter are expelled with immense force.

First proposed in the 1970s, white holes are essentially black holes in reverse. They rely on the same equations of general relativity but with time flowing in the opposite direction. While a black hole pulls matter in and lets nothing escape, a white hole would repel matter, releasing high-energy radiation and light.

Despite their intriguing properties, white holes face significant scientific challenges. The laws of thermodynamics, particularly entropy, make it improbable for matter to move backward in time, as white holes would require. Additionally, introducing a singularity into the Universe without a preceding collapse defies current understanding of cosmic evolution.

Neutrinos, Dark Energy, and Einstein: DESI Maps the Universe’s Secrets

New analysis supports Einstein’s relativity and narrows neutrino mass ranges, hinting at evolving dark energy.

Gravity, the fundamental force sculpting the universe, has shaped tiny variations in matter from the early cosmos into the vast networks of galaxies we see today. Using data from the Dark Energy Spectroscopic Instrument (DESI), scientists have traced the evolution of these cosmic structures over the past 11 billion years. This research represents the most precise large-scale test of gravity ever conducted, offering unprecedented insights into the universe’s formation and behavior.

Introduction to DESI and its global impact.

Robert Stone & Dr. Marcel van den Brink — City of Hope — Innovative, Compassionate Accessible Care

Delivering Innovative, Compassionate And Accessible Patient Care — Robert Stone, CEO — City of Hope & Dr. Marcel van den Brink, MD, PhD, President, City of Hope Comprehensive Cancer Center.

Robert Stone is the CEO of City of Hope (https://www.cityofhope.org/robert-stone), a premier cancer research and treatment center dedicated to innovation in biomedical science and the delivery of compassionate, world-class patient care. A seasoned health care executive, he has served in a number of strategic decision-making roles since he joined City of Hope in 1996, culminating with his appointment as president in 2012, CEO in 2014, and as the Helen and Morgan Chu Chief Executive Officer Distinguished Chair in 2021.

Mr. Stone has J.D., University of Chicago Law School, Chicago, IL.

Mr. Stone’s strategic acumen, empathy and visionary leadership have driven City of Hope’s rapid evolution.

As an independent institution dedicated to advancing the fight against cancer and diabetes, City of Hope is accelerating opportunities for high-impact discovery and ensuring that patients around the world have access to the most advanced therapies. Recent examples include a groundbreaking alliance in precision medicine with the Translational Genomics Research Institute (TGen), a leader in genomic analysis and bioinformatics; leadership in CAR T cell therapy research and therapy; and an innovative program to offer cancer support services to the employees of some of American’s largest employers, regardless of geography.

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Novel technique uses magnetic fields to probe long-term aging in batteries

Researchers at the U.S. Department of Energy’s (DOE) Argonne National Laboratory have developed and demonstrated an innovative set of methods to evaluate long-term aging in real-world battery cells. The methods, described in a recent paper, are based on a phenomenon called nuclear magnetic resonance (NMR), commonly used in medical imaging. This is the first-ever NMRspectroscopy capability that can track in fine detail how the chemistry of commercial pouch battery cells evolves over years of operation.

Argonne develops a novel method that uses nuclear magnetic resonance spectroscopy to characterize the chemical evolution inside battery cells over years of operation.