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Learning from catastrophe

Engineers are renowned clock-problem solvers. They’re also notorious for treating every problem like a clock. Increasing specialization and cultural expectations play a role in this tendency. But so do engineers themselves, who are typically the ones who get to frame the problems they’re trying to solve in the first place.

In his latest book, Wicked Problems, Guru Madhavan argues that the growing number of cloudy problems in our world demands a broader, more civic-minded approach to engineering. “Wickedness” is Madhavan’s way of characterizing what he calls “the cloudiest of problems.” It’s a nod to a now-famous coinage by Horst Rittel and Melvin Webber, professors at the University of California, Berkeley, who used the term “wicked” to describe complex social problems that resisted the rote scientific and engineering-based (i.e., clock-like) approaches that were invading their fields of design and urban planning back in the 1970s.

Madhavan, who’s the senior director of programs at the National Academy of Engineering, is no stranger to wicked problems himself. He’s tackled such daunting examples as trying to make prescription drugs more affordable in the US and prioritizing development of new vaccines. But the book isn’t about his own work. Instead, Wicked Problems weaves together the story of a largely forgotten aviation engineer and inventor, Edwin A. Link, with case studies of man-made and natural disasters that Madhavan uses to explain how wicked problems take shape in society and how they might be tamed.

‘Gut-on-chip’ can predict immunotherapy outcomes for melanoma patients

A team of researchers has developed a “gut-on-chip” (a miniature model of the human intestine on a chip-sized device) capable of reproducing the main features of intestinal inflammation and of predicting the response of melanoma patients to immunotherapy treatment. The results have just been published in Nature Biomedical Engineering.

The interaction between microbiota and has long been known. It is the result of both systemic effects, i.e., the elicited in the entire body by immunotherapy, and local processes, especially in the gut, where most of the bacteria that populate our body live. However, the latter can only be studied in animal models, with all their limitations.

Indeed, there is no clinical reason to subject a patient receiving immunotherapy for melanoma to colonoscopy and colon biopsy. Yet intestinal inflammation is one of the main side effects of this treatment, often forcing the therapy to be discontinued.

Scientists Think They Could Revolutionize Computing by Leveraging Quantum Teleportation

To test this new system, the team executed what is known as Grover’s search algorithm—first described by Indian-American computer scientist Lov Grover in 1996. This search looks for a particular item in a large, unstructured dataset using superposition and entanglement in parallel. The search algorithm also exhibits a quadratic speedup, meaning a quantum computer can solve a problem with the square root of the input rather than just a linear increase. The authors report that the system achieved a 71 percent success rate.

While operating a successful distributed system is a big step forward for quantum computing, the team reiterates that the engineering challenges remain daunting. However, networking together quantum processors into a distributed network using quantum teleportation provides a small glimmer of light at the end of a long, dark quantum computing development tunnel.

“Scaling up quantum computers remains a formidable technical challenge that will likely require new physics insights as well as intensive engineering effort over the coming years,” David Lucas, principal investigator of the study from Oxford University, said in a press statement. “Our experiment demonstrates that network-distributed quantum information processing is feasible with current technology.”

Quantum-inspired advancement turns crystal gaps into terabyte storage for classical memory

From punch card-operated looms in the 1800s to modern cellphones, if an object has an “on” and an “off” state, it can be used to store information.

In a computer laptop, the binary ones and zeroes are transistors either running at low or high voltage. On a compact disc, the one is a spot where a tiny indented “pit” turns to a flat “land” or vice versa, while a zero is when there’s no change.

Historically, the size of the object making the “ones” and “zeroes” has put a limit on the size of the storage device. But now, University of Chicago Pritzker School of Molecular Engineering (UChicago PME) researchers have explored a technique to make ones and zeroes out of crystal defects, each the size of an individual atom for classical computer memory applications.

Light-activated Ink Developed to Remotely Control Cardiac Tissue to Repair the Heart

Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue. Their goal is to develop a technique that can be used to repair the heart. Their findings in preclinical models, published in Science Advances, show the transformative potential of non-invasive therapeutic methods to control electrically active tissues.

“We showed for the first time that with this optoelectronically active ink, we can print scaffolds that allow remote control of engineered heart tissues,” said co-corresponding author Y. Shrike Zhang, Ph.D., of the Division of Engineering in Medicine at Brigham and Women’s Hospital, a founding member of the Mass General Brigham health care system. “This approach paves the way for non-invasive light stimulation, tissue regeneration, and host integration capabilities in cardiac therapy and beyond.”

Three-dimensional bioprinted tissues composed of cells and other body-compatible materials are a powerful emerging tool to repair damaged heart tissue. But most bioprinted tissues cannot generate the necessary electrical activity for cellular function. They must instead rely on invasive wire and electrode placement to control heart activity, which can damage body tissues.

Generating record-speed waves on extremely water-repellent surfaces

Ripples, like ones produced by raindrops falling in a puddle, are also called capillary waves. Studied since antiquity, they have garnered considerable interest in modern science due to their ability to reveal information about the medium on which they travel. This makes them particularly valuable for studying soft and biological matter in microfluidic applications, which focus on how fluids behave in microscopic environments.

Now physicists and from Aalto University’s Department of Neuroscience and Biomedical Engineering and Department of Applied Physics have unearthed new characteristics of capillary waves, setting a record for their speed while doing so.

The paper is published in Nature Communications.

Entangling two physically separate resonators enables a major advance in the science of quantum sound

Entanglement—linking distant particles or groups of particles so that one cannot be described without the other—is at the core of the quantum revolution changing the face of modern technology.

While entanglement has been demonstrated in very small particles, new research from the lab of University of Chicago Pritzker School of Molecular Engineering (UChicago PME) Prof. Andrew Cleland is thinking big, demonstrating high-fidelity entanglement between two acoustic wave resonators.

The paper is published in Nature Communications.

Altilium files patent application for its EcoCathode™ recycling process

Altilium has filed a patent application for its proprietary EcoCathode™ recycling process, underlining its technical leadership in the UK and its commitment to establishing a national champion for EV battery recycling.

The patent provides a process, apparatus and system for recovering battery metals (such as cobalt, manganese, nickel and lithium) and graphite, and the production of battery precursors and battery-ready cathode active materials (CAM), from black mass (comprising a mixed feed of critical compounds or elements).

Through microstructure reengineering, Altilium’s EcoCathode™ process represents a significant stride in clean technology and sustainable EV battery recycling in the UK. Recovering over 95% of crucial metals from old EV batteries, the technology will contribute to a sustainable domestic supply of battery raw materials, reducing carbon emissions by over 50% and reducing the cost of CAM by more than 20% compared to conventional virgin mining practices.

Mars Terraforming Not Possible Using Present-Day Technology

Science fiction writers have long featured terraforming, the process of creating an Earth-like or habitable environment on another planet, in their stories. Scientists themselves have proposed terraforming to enable the long-term colonization of Mars. A solution common to both groups is to release carbon dioxide gas trapped in the Martian surface to thicken the atmosphere and act as a blanket to warm the planet.

However, Mars does not retain enough carbon dioxide that could practically be put back into the atmosphere to warm Mars, according to a new NASA-sponsored study. Transforming the inhospitable Martian environment into a place astronauts could explore without life support is not possible without technology well beyond today’s capabilities.

Dr. Amir Baniassadi, Ph.D. — Marcus Institute for Aging Research — Environmental Gerontology

Environmental Gerontology & Vulnerability Science For Health And Well-Being — Dr. Amir Baniassadi, Ph.D. — Marcus Institute for Aging Research, Hebrew SeniorLife / Harvard Medical School.


Dr. Amir Baniassadi, Ph.D. is an Instructor of Medicine at Harvard Medical School and an Assistant Scientist in Marcus Institute for Aging Research (https://www.marcusinstituteforaging.o… where he works on environmental impacts on health and well-being of older populations.

Dr. Baniassadi works on the impacts of ambient air temperature and air quality (both indoors and outdoors) on outcomes related to the health and well-being of physiologically and socioeconomically vulnerable populations. His research applies novel environmental modeling and measurement techniques along with remote and long-term physiological and functional monitoring of individuals to establish relationships between exposure and outcome variables of interest outside clinical lab settings. The ultimate goal of his research is to develop environmental interventions that optimize the environment for health and longevity of older adults.

Dr. Baniassadi has a Ph.D. in Civil, Environmental, and Sustainable Engineering from Arizona State University and a B.Sc. degree in Mechanical Engineering from the University of Tehran. His post-doctoral training includes a three-year T32 fellowship in Translational Research in Older adults, and a two-year postdoctoral fellowship at Harvard University Graduate School of Design.

#AmirBaniassadi #HarvardMedicalSchool #MarcusInstituteForAgingResearch #EnvironmentalGerontology #VulnerabilityScience #Exposome #Health #WellBeing #Wearables #SmartHome #AgingInPlace #Thermoregulation #HeatIslands.

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