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Category: engineering – Page 143

Microsoft Health-Tech Vision

Dr. James Weinstein, is Senior Vice President, Microsoft Healthcare, where he is in charge of leading strategy, innovation and health equity functions.

Prior to Microsoft, Dr. Weinstein was president and CEO of Dartmouth-Hitchcock Health, a $2.0 billion academic medical center in Northern New England, where he led the organization to adopt a population health model, including the transition from fee-for-service toward global payments.

Prior to becoming CEO, Dr. Weinstein served as president of Dartmouth-Hitchcock Clinic and was director of The Dartmouth Institute for Health Policy and Clinical Practice (TDI), home of the Dartmouth Atlas of Health Care, which for decades has documented the ongoing variations in health care delivery across the United States.

Dr. Weinstein is a founding member and the inaugural executive director of the National High Value Healthcare Collaborative, along with Mayo Clinic, Intermountain Healthcare, The Dartmouth Institute, and Denver Health. The Collaborative is a partnership of health systems that has taken on the challenge of improving the quality of care while lowering costs on a national scale.

Continue reading “Dr. James Weinstein, SVP Microsoft — Creating Healthcare With Value, Outcomes & Equity For Patients” | >

To visually illustrate the risk of airborne transmission in real time, The Washington Post used a military-grade infrared camera capable of detecting exhaled breath. Numerous experts — epidemiologists, virologists and engineers — supported the notion of using exhalation as a conservative proxy to show potential transmission risk in various settings.

“The images are very, very telling,” said Rajat Mittal, a professor of mechanical engineering in Johns Hopkins University’s medical and engineering schools and an expert on virus transmission. “Getting two people and actually visualizing what’s happening between them, that’s very invaluable.”

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Drexel University researchers are one step closer to offering a new treatment for the millions of patients who suffer from slow-healing, chronic wounds. The battery-powered applicator — as small and light as a watch — is the first portable and potentially wearable device to heal wounds with low-frequency ultrasound.

The National Institutes of Health (NIH) has awarded the research team an estimated $3 million to test the therapy on 120 patients over the next five years. By using diagnostic monitoring of blood flow in the wound tissue, the clinical trial will also determine how nutrition and inflammation impact wound closure, making treatment customization a possibility.

The project is an interdisciplinary collaboration between Drexel’s School of Biomedical Engineering, Science and Health Systems, the College of Medicine and the College of Nursing and Health Professions.

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The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip. Through a combination of cell biology, engineering, and biomaterial technology, the microenvironment of the chip simulates that of the organ in terms of tissue interfaces and mechanical stimulation. This reflects the structural and functional characteristics of human tissue and can predict response to an array of stimuli including drug responses and environmental effects. OOAC has broad applications in precision medicine and biological defense strategies. Here, we introduce the concepts of OOAC and review its application to the construction of physiological models, drug development, and toxicology from the perspective of different organs. We further discuss existing challenges and provide future perspectives for its application.

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In recent years, it has become possible to use laser beams and electron beams to “print” engineering objects with complex shapes that could not be achieved by conventional manufacturing. The additive manufacturing (AM) process, or 3D printing, for metallic materials involves melting and fusing fine-scale powder particles—each about 10 times finer than a grain of beach sand—in sub-millimeter-scale “pools” created by focusing a laser or electron beam on the material.

“The highly focused beams provide exquisite control, enabling ‘tuning’ of properties in critical locations of the printed object,” said Tresa Pollock, a professor of materials and associate dean of the College of Engineering at UC Santa Barbara. “Unfortunately, many advanced metallic alloys used in extreme heat-intensive and chemically corrosive environments encountered in energy, space and nuclear applications are not compatible with the AM process.”

The challenge of discovering new AM-compatible materials was irresistible for Pollock, a world-renowned scientist who conducts research on advanced metallic materials and coatings. “This was interesting,” she said, “because a suite of highly compatible alloys could transform the production of having high economic value—i.e. materials that are expensive because their constituents are relatively rare within the earth’s crust—by enabling the manufacture of geometrically complex designs with minimal material waste.

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Serena Corr looks at the science behind batteries, discusses why we are hunting for new ones and investigates what tools we use to pave this pathway to discovery.
Watch the Q&A: https://youtu.be/lZjqiR0czLo.

The hunt is on for the next generation of batteries that will power our electric vehicles and help our transition to a renewables-led future. Serena shows how researchers at the Faraday Institution are developing new chemistries and manufacturing processes to deliver safer, cheaper, and longer-lasting batteries and provide higher power or energy densities for electric vehicles.

Serena Corr is a Chair in Functional Materials and Professor in Chemical and Biological Engineering at the University of Sheffield. She works on next-generation battery materials and advanced characterisation techniques for nanomaterials.

This event was generously supported by The Faraday Institution.

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Continue reading “The Hunt for New Batteries — with Serena Corr” | >

Hypersonic flight is conventionally referred to as the ability to fly at speeds significantly faster than the speed of sound and presents an extraordinary set of technical challenges. As an example, when a space capsule re-enters Earth’s atmosphere, it reaches hypersonic speeds—more than five times the speed of sound—and generates temperatures over 4,000 degrees Fahrenheit on its exterior surface. Designing a thermal protection system to keep astronauts and cargo safe requires an understanding at the molecular level of the complicated physics going on in the gas that flows around the vehicle.

Recent research at the University of Illinois Urbana-Champaign added new knowledge about the physical phenomena that occur as atoms vibrate, rotate, and collide in this extreme environment.

“Due to the relative velocity of the flow surrounding the vehicle, a shock is formed in front of the capsule. When the gas molecules cross the shock, some of their properties change almost instantaneously. Instead, others don’t have enough time to adjust to the abrupt changes, and they don’t reach their equilibrium values before arriving at the surface of the vehicle. The layer between the shock and heat shield is then found in nonequilibrium. There is a lot that we don’t understand yet about the reactions that happen in this type of flow,” said Simone Venturi. He is a graduate student studying with Marco Panesi in the Department of Aerospace Engineering at UIUC.

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Graphene, an atomically thin carbon layer through which electrons can travel virtually unimpeded, has been extensively studied since its first successful isolation more than 15 years ago. Among its many unique properties is the ability to support highly confined electromagnetic waves coupled to oscillations of electronic charge—plasmon polaritons—that have potentially broad applications in nanotechnology, including biosensing, quantum information, and solar energy.

However, in order to support , must be charged by applying a voltage to a nearby metal gate, which greatly increases the size and complexity of nanoscale devices. Columbia University researchers report that they have achieved plasmonically active graphene with record-high charge density without an external gate. They accomplished this by exploiting novel interlayer charge transfer with a two-dimensional electron-acceptor known as α-RuCl3. The study is available now online as an open access article and will appear in the December 9th issue of Nano Letters.

“This work allows us to use graphene as a plasmonic material without metal gates or voltage sources, making it possible to create stand-alone graphene plasmonic structures for the first time” said co-PI James Hone, Wang Fong-Jen Professor of Mechanical Engineering at Columbia Engineering.

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Simulations that model molecular interactions have identified an enzyme that could be targeted to reverse a called cellular senescence. The findings were validated with laboratory experiments on and equivalent tissues, and published in the Proceedings of the National Academy of Sciences (PNAS).

“Our research opens the door for a new generation that perceives aging as a reversible biological phenomenon,” says Professor Kwang-Hyun Cho of the Department of Bio and Brain engineering at the Korea Advanced Institute of Science and Technology (KAIST), who led the research with colleagues from KAIST and Amorepacific Corporation in Korea.

Cells respond to a variety of factors, such as oxidative stress, DNA damage, and shortening of the telomeres capping the ends of chromosomes, by entering a stable and persistent exit from the . This process, called cellular senescence, is important, as it prevents damaged from proliferating and turning into . But it is also a natural process that contributes to aging and . Recent research has shown that cellular senescence can be reversed. But the laboratory approaches used thus far also impair tissue regeneration or have the potential to trigger malignant transformations.

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