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Category: engineering – Page 127

New method melds data to make a 3D map of cells’ activities

Just as it’s hard to understand a conversation without knowing its context, it can be difficult for biologists to grasp the significance of gene expression without knowing a cell’s environment. To solve that problem, researchers at Princeton Engineering have developed a method to elucidate a cell’s surroundings so that biologists can make more meaning of gene expression information.

The researchers, led by Professor of Computer Science Ben Raphael, hope the new system will open the door to identifying rare cell types and choosing cancer treatment options with new precision. Raphael is the senior author of a paper describing the method published May 16 in Nature Methods.

The basic technique of linking with a cell’s environment, called spatial transcriptomics (ST), has been around for several years. Scientists break down onto a microscale grid and link each spot on the grid with information about gene expression. The problem is that current computational tools can only analyze spatial patterns of gene expression in two dimensions. Experiments that use multiple slices from a single tissue sample—such as a region of a brain, heart or tumor—are difficult to synthesize into a complete picture of the cell types in the tissue.

Twitter shareholders sue Musk, claim he sought to drive down stock price

All I can say is that I hope his self indulgence for his favorite ☆HOBBY☆ — Twitter itself — doesn’t sabotage the interplanetary future he’s defined and actually begun to to successfully realize, doing so against all odds in so many fields, cas diverse as science, engineering, economics, politics, and the recent history and the seeming decline in public enthusiasm, funding, and any sort of clear direction. He didn’t just subvert those roadblocks, he OBLITERATED them. SPECTACULARLY.

All that progress and innovation can and WILL be undone in seconds if he makes himself into an allie of a republican party that has abandoned truth, abandoned science, and abandoned every semblance of honor, loyalty, and reason.

A republican party that has abandoned Democracy ITSELF.

Twitter shareholders have filed a lawsuit accusing Elon Musk of engaging in “unlawful conduct” aimed at sowing doubt about his bid to buy the social media company.

The lawsuit filed late Wednesday in the U.S. District Court for the Northern District of California claims the billionaire Tesla chief executive has sought to drive down Twitter’s stock price because he wants to walk away from the deal or negotiate a substantially lower purchase price.

San Francisco-based Twitter is also named as a defendant in the lawsuit, which seeks class-action status as well as compensation for damages.

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How the universe got its magnetic field

When we look out into space, all of the astrophysical objects that we see are embedded in magnetic fields. This is true not only in the neighborhood of stars and planets, but also in the deep space between galaxies and galactic clusters. These fields are weak—typically much weaker than those of a refrigerator magnet—but they are dynamically significant in the sense that they have profound effects on the dynamics of the universe. Despite decades of intense interest and research, the origin of these cosmic magnetic fields remains one of the most profound mysteries in cosmology.

In previous research, scientists came to understand how turbulence, the churning motion common to fluids of all types, could amplify preexisting magnetic fields through the so-called dynamo process. But this remarkable discovery just pushed the mystery one step deeper. If a turbulent dynamo could only amplify an existing field, where did the “seed” magnetic field come from in the first place?

We wouldn’t have a complete and self-consistent answer to the origin of astrophysical magnetic fields until we understood how the seed fields arose. New work carried out by MIT graduate student Muni Zhou, her advisor Nuno Loureiro, a professor of nuclear science and engineering at MIT, and colleagues at Princeton University and the University of Colorado at Boulder provides an answer that shows the basic processes that generate a field from a completely unmagnetized state to the point where it is strong enough for the dynamo mechanism to take over and amplify the field to the magnitudes that we observe.

New electronics cooling tech enables 740% increase in power per unit volume

Tarek Gebrael, a UIUC Ph.D. student in mechanical engineering, explains that the existing solutions suffer from three shortcomings – first, they can be expensive and difficult to scale up. Second, conventional heat spreading approaches generally require that the heat spreader and a heat sink be attached on top of the electronics device. Unfortunately, in many cases, most of the heat is generated underneath the electronic devices, meaning that the cooling mechanism isn’t where it is needed the most.

And third, Gebrael explained, the heat spreaders can’t be installed directly on the surface of the electronics. They require a layer of “thermal interface material” sandwiched between them to ensure good contact. However, due to its poor heat transfer characteristics, that middle layer also introduces a negative impact on thermal performance.

Now, researchers have come up with a new solution to address all three of those problems. First, they used copper as a primary material, which is relatively inexpensive. They then made the copper coating that entirely “engulfs” the device, says Gebrael, “covering the top, the bottom, and the sides… a conformal coating that covers all the exposed surfaces” – so that no heat-producing regions are neglected. And finally, the new solution removes the need for a thermal interface material and a heat sink.

Engineering 2D semiconductors with built-in memory functions

A team of researchers at The University of Manchester’s National Graphene Institute (NGI) and the National Physical Laboratory (NPL) has demonstrated that slightly twisted 2D transition metal dichalcogenides (TMDs) display room-temperature ferroelectricity.

This characteristic, combined with TMDs’ outstanding optical properties, can be used to build multi-functional optoelectronic devices such as transistors and LEDs with built-in memory functions on nanometre length scale.

Ferroelectrics are materials with two or more electrically polarisable states that can be reversibly switched with the application of an external electric field. This material property is ideal for applications such as non-volatile memory, microwave devices, sensors and transistors. Until recently, out-of-plane switchable ferroelectricity at room temperature had been achieved only in films thicker than 3 nanometres.

Imperial students find innovative new use for lobster shell waste

The four students are studying Innovation Design Engineering, a course delivered jointly by Imperial College London and the Royal College of Art. They have built a series of machines that extract, form and recycle the material, which they believe could be used as a replacement for various single-use plastics.

The project uses chitin, the world’s second most abundant biopolymer, (a naturally produced plastic). Chitin is found in crustaceans, insects and fungi, but needs to be chemically extracted from the source before it can be turned into the material.

The group of students have developed new manufacturing processes to transform lobster shell waste into biodegradable, recyclable bioplastic.

Termination Shock: Trying To Cool the Earth

A group of 60 scientists called for a moratorium on solar geoengineering last month, including technologies such as stratospheric aerosol injection (SAI). This involves a fleet of aeroplanes releasing aerosol particles – which reflect sunlight back to outer space – into the atmosphere, cooling down the Earth.

SAI might make the sky slightly whiter. But this is the least of our concerns. SAI could pose grave dangers, potentially worse than the warming it seeks to remedy. To understand the risks, we’ve undertaken a risk assessment of this controversial technology.

A cooler Earth means less water would be evaporating from its surfaces into the atmosphere, changing rainfall patterns. This could produce ripple effects across the world’s ecosystems – but the exact nature of these effects depends on how SAI is used. Poor coordination of aerosol release could lead to extreme rainfall in some places and blistering drought in others, further triggering the spread of diseases.

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