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Category: chemistry – Page 376

Smellicopter Tiny Drone Uses Moth Antenna to Find Smells

Meet the Smellicopter is a tiny drone developed by scientists at the University of Washington, capable of detecting smells like gas leaks, explosives, or even the survivors of a natural disaster. This amazing, obstacle avoiding UAV doesn’t use a man-made sensor to smell: it uses a moth antenna to navigate towards an odor.

A research paper published in IOP Science describes Smellicopter as “A bio-hybrid odor-guided autonomous palm-sized air vehicle.” The advantages to such a vehicle are clear: the tiny drone can travel in places that humans cannot or should not: the rubble of buildings after a natural disaster; zones where chemical leaks or spills may have occurred; or conflict zones that may contain chemical or explosive weapons.

The truly unique aspect of this amazing little drone is the use of a moth antenna: tiny, delicate, and amazingly sensitive.

A molecule that works like a nanobattery

How do molecular catalysts—molecules which, like enzymes, can trigger or accelerate certain chemical reactions—function, and what effects do they have? A team of chemists at the University of Oldenburg has come closer to the answers using a model molecule that functions like a molecular nanobattery. It consists of several titanium centers linked to each other by a single layer of interconnected carbon and nitrogen atoms. The seven-member research team recently published its findings, which combine the results of three multi-year Ph.D. research projects, in ChemPhysChem. The physical chemistry and chemical physics journal featured the basic research from Oldenburg on its cover.

To gain a better understanding of how the molecule works, the researchers, headed by first authors Dr. Aleksandra Markovic and Luca Gerhards and corresponding author Prof. Dr. Gunther Wittstock, performed electrochemical and spectroscopic experiments and used the university’s high-performance computing cluster for their calculations. Wittstock sees the publication of the paper as a “success story” for both the Research Training Groups within which the Ph.D. projects were conducted and for the university’s computing cluster. “Without the high-performance computing infrastructure, we would not have been able to perform the extensive calculations required to decipher the behavior of the molecule,” says Wittstock. “This underlines the importance of such computing clusters for current research.”

In the paper, the authors present the results of their analysis of a molecular structure, the prototype for which was the result of an unexpected chemical reaction first reported by the University of Oldenburg’s Chemistry Department in 2006. It is a highly complex molecular structure in which three titanium centers (commonly referred to in high school lessons as titanium ions) are connected to each other by a bridging ligand consisting of carbon and nitrogen. Such a compound would be expected to be able to accept and release several electrons through the exchange of electrons between the metal centers among other reasons.

Common pipe alloy can form cancer-causing chemical in drinking water

Rusted iron pipes can react with residual disinfectants in drinking water distribution systems to produce carcinogenic hexavalent chromium in drinking water, reports a study by engineers at UC Riverside.

Chromium is a metal that occurs naturally in the soil and groundwater. Trace amounts of trivalent eventually appear in the and food supply and are thought to have neutral effects on health. Chromium is often added to iron to make it more resistant to corrosion.

Certain can change chromium atoms into a hexavalent form that creates cancer-causing genetic mutations in cells. This carcinogenic form of chromium was at the heart of a lawsuit in California’s Central Valley by Erin Brockovich, which became the subject of an Oscar-winning movie.

Magdrive secures Seed funding for new propulsion system which could take us to the stars

A startup with a new type of spacecraft propulsion system could make the interplanetary travel seen in Star Trek a reality. Magdrive has just closed a £1.4M seed round led by Founders Fund, an early investor in SpaceX, backed by Luminous Ventures, 7percent Ventures, and Entrepreneur First.

Magdrive is developing a next generation of spacecraft propulsion for small satellites. The startup says its engine’s thrust and efficiency are a “generational leap” ahead of any other electrical thrusters, opening up the space industry to completely new types of missions that were not possible before, without resorting to much larger, expensive and heavier chemical thrusters. It says its engine would make fast and affordable interplanetary space travel possible, as well as operations in Very Low Earth orbit. The engine would also make orbital manufacturing far more possible than previously.

Existing electrical solutions are very efficient but have very low thrust. Chemical thrusters have high thrust but lack efficiency and are hazardous and expensive to handle. Magdrive says its engine can deliver both high thrust and high efficiency in one system.

Chemical Compounds in Foods Can Inhibit a Key SARS-CoV-2 Enzyme

““Green tea has five tested chemical compounds that bind to different sites in the pocket on Mpro, essentially overwhelming it to inhibit its function,” Xie said. “Muscadine grapes contain these inhibitory chemicals in their skins and seeds. Plants use these compounds to protect themselves, so it is not surprising that plant leaves and skins contain these beneficial compounds.””

Glad I picked up a refill on my resveratrol this week!

Green tea, muscadine grape and dark chocolate chemical compounds inhibit an important SARS-CoV-2 enzyme.

Salt-tolerant bacteria with an appetite for sludge make biodegradable plastics

The United States generates seven million tons of sewage sludge annually, enough to fill 2, 500 Olympic-sized swimming pools. While a portion of this waste is repurposed for manure and other land applications, a substantial amount is still disposed of in landfills. In a new study, Texas A&M University researchers have uncovered an efficient way to use leftover sludge to make biodegradable plastics.

In the September issue of the journal American Chemical Society (ACS) Omega, the researchers report that the bacterium Zobellella denitrificans ZD1, found in mangroves, can consume sludge and wastewater to produce polyhydroxybutyrate, a type of biopolymer that can be used in lieu of petroleum-based plastics. In addition to reducing the burden on landfills and the environment, the researchers said Zobellella denitrificans ZD1 offers a way to cut down upstream costs for bioplastics manufacturing, a step toward making them more competitively priced against regular plastics.

“The price of raw materials to cultivate biopolymer-producing bacteria accounts for 25–45% of the total production cost of manufacturing bioplastics. Certainly, this cost can be greatly reduced if we can tap into an alternate resource that is cheaper and readily obtainable,” said Kung-Hui (Bella) Chu, professor in the Zachry Department of Civil and Environmental Engineering. “We have demonstrated a potential way to use municipal wastewater-activated sludge and agri-and aqua-culture industrial wastewater to make biodegradable plastics. Furthermore, the does not require elaborate sterilization processes to prevent contamination from other microbes, further cutting down operating and production costs of bioplastics.”

LED lights found to kill coronavirus: Global first in fight against COVID-19

Am I reading this wrong? Sunelight is literally a cure / weapon against corona? Or am I missing something / making an incorrect logical link?

Researchers from Tel Aviv University (TAU) have proven that the coronavirus can be killed efficiently, quickly, and cheaply using ultraviolet (UV) light-emitting diodes (UV-LEDs). They believe that the UV-LED technology will soon be available for private and commercial use.

This is the first study conducted on the disinfection efficiency of UV-LED irradiation at different wavelengths or frequencies on a virus from the family of coronaviruses. The study was led by Professor Hadas Mamane, Head of the Environmental Engineering Program at TAU’s School of Mechnical Engineering, Iby and Aladar Fleischman Faculty of Engineering. The article was published in November 2020 issue of the Journal of Photochemistry and Photobiology B: Biology.

“The entire world is currently looking for effective solutions to disinfect the coronavirus,” said Professor Mamane. “The problem is that in order to disinfect a bus, train, sports hall, or plane by chemical spraying, you need physical manpower, and in order for the spraying to be effective, you have to give the chemical time to act on the surface. Disinfection systems based on LED bulbs, however, can be installed in the ventilation system and air conditioner, for example, and sterilize the air sucked in and then emitted into the room.

Chemicals used to make non-stick pans linked to rapid weight gain

Better doublecheck your kitchenware! 😃

The results indicate that environmental chemicals may be an important contributing factor to the obesity epidemic. Unfortunately, it is practically impossible to avoid exposure to PFASs as they have been widely used in products like cookware, clothes, shoes, wrappers and furniture, to make them more stain-resistant, waterproof and/or nonstick.

Additionally, even though some PFASs (but not all) are no longer manufactured in the U.S., they continue to be in other countries around the globe. The long life of the chemicals and their ability to travel long distances through the air makes exposure possible even years after manufacturing and at completely different geographical locations.

Nevertheless, Sun gives one more reason to stop eating junk food: “We know that PFAS exist in food packaging materials, like fast-food wrappers and microwave popcorn bags. If you don’t eat those foods, you can possibly reduce your exposure.”

Physicists fine tune chemical reaction rates for ultracold molecules

New technique could be useful for quantum information processing.

A new technique to cool reactive molecules to temperatures low enough to achieve quantum degeneracy – something not generally possible before – has been created by researchers in the US. In this temperature regime, the dominance of quantum effects over thermal fluctuations should allow researchers to study new quantum properties of molecules. As a first example, the researchers demonstrated how a slight change in applied electric field can alter the reaction rate between molecules by three orders of magnitude. The researchers hope their platform will enable further exploration of molecular quantum degeneracy, with potential applications ranging from quantum many body physics to quantum information processing.

When atoms are cooled close to absolute zero, the blur created by thermal effects that govern their behaviour in the classical world around us is removed, making their quantum nature clear. This has led to some fascinating discoveries. In ultracold quantum bosonic or fermion-pair quantum gases, for example, all the atoms in a trap can simultaneously occupy the quantum ground state, resulting in a wavefunction that is macroscopic.

Cooling and trapping molecules is much trickier because they are inherently more complex than atoms. Whereas atoms can only contain quanta of energy in electronic excitations, the chemical bonds in molecules can stretch, rotate and bend – and cooling molecules involves removing energy from all of these degrees of freedom. Moreover, the complexity of molecules increases the complexity of their collisions. Although elastic collisions are necessary to knock the fastest-moving molecules out of a trap and cool it, inelastic collisions dissipate heat in the trap.

Genetic engineering transformed stem cells into working mini-livers that extended the life of mice with liver disease

Takeaways * Scientists have made progress growing human liver in the lab. * The challenge has been to direct stems cells to grow into a mature, functioning adult organ. * This study shows that stem cells can be programmed, using genetic engineering, to grow from immature cells into mature tissue. * When a tiny lab-grown liver was transplanted into mice with liver disease, it extended the lives of the sick animals.* * *Imagine if researchers could program stem cells, which have the potential to grow into all cell types in the body, so that they could generate an entire human organ. This would allow scientists to manufacture tissues for testing drugs and reduce the demand for transplant organs by having new ones grown directly from a patient’s cells. I’m a researcher working in this new field – called synthetic biology – focused on creating new biological parts and redesigning existing biological systems. In a new paper, my colleagues and I showed progress in one of the key challenges with lab-grown organs – figuring out the genes necessary to produce the variety of mature cells needed to construct a functioning liver. Induced pluripotent stem cells, a subgroup of stem cells, are capable of producing cells that can build entire organs in the human body. But they can do this job only if they receive the right quantity of growth signals at the right time from their environment. If this happens, they eventually give rise to different cell types that can assemble and mature in the form of human organs and tissues. The tissues researchers generate from pluripotent stem cells can provide a unique source for personalized medicine from transplantation to novel drug discovery. But unfortunately, synthetic tissues from stem cells are not always suitable for transplant or drug testing because they contain unwanted cells from other tissues, or lack the tissue maturity and a complete network of blood vessels necessary for bringing oxygen and nutrients needed to nurture an organ. That is why having a framework to assess whether these lab-grown cells and tissues are doing their job, and how to make them more like human organs, is critical. Inspired by this challenge, I was determined to establish a synthetic biology method to read and write, or program, tissue development. I am trying to do this using the genetic language of stem cells, similar to what is used by nature to form human organs. Tissues and organs made by genetic designsI am a researcher specializing in synthetic biology and biological engineering at the Pittsburgh Liver Research Center and McGowan Institute for Regenerative Medicine, where the goals are to use engineering approaches to analyze and build novel biological systems and solve human health problems. My lab combines synthetic biology and regenerative medicine in a new field that strives to replace, regrow or repair diseased organs or tissues. I chose to focus on growing new human livers because this organ is vital for controlling most levels of chemicals – like proteins or sugar – in the blood. The liver also breaks down harmful chemicals and metabolizes many drugs in our body. But the liver tissue is also vulnerable and can be damaged and destroyed by many diseases, such as hepatitis or fatty liver disease. There is a shortage of donor organs, which limits liver transplantation. To make synthetic organs and tissues, scientists need to be able to control stem cells so that they can form into different types of cells, such as liver cells and blood vessel cells. The goal is to mature these stem cells into miniorgans, or organoids, containing blood vessels and the correct adult cell types that would be found in a natural organ. One way to orchestrate maturation of synthetic tissues is to determine the list of genes needed to induce a group of stem cells to grow, mature and evolve into a complete and functioning organ. To derive this list I worked with Patrick Cahan and Samira Kiani to first use computational analysis to identify genes involved in transforming a group of stem cells into a mature functioning liver. Then our team led by two of my students – Jeremy Velazquez and Ryan LeGraw – used genetic engineering to alter specific genes we had identified and used them to help build and mature human liver tissues from stem cells. The tissue is grown from a layer of genetically engineered stem cells in a petri dish. The function of genetic programs together with nutrients is to orchestrate formation of liver organoids over the course of 15 to 17 days. Liver in a dishI and my colleagues first compared the active genes in fetal liver organoids we had grown in the lab with those in adult human livers using a computational analysis to get a list of genes needed for driving fetal liver organoids to mature into adult organs. We then used genetic engineering to tweak genes – and the resulting proteins – that the stem cells needed to mature further toward an adult liver. In the course of about 17 days we generated tiny – several millimeters in width – but more mature liver tissues with a range of cells typically found in livers in the third trimester of human pregnancies. Like a mature human liver, these synthetic livers were able to store, synthesize and metabolize nutrients. Though our lab-grown livers were small, we are hopeful that we can scale them up in the future. While they share many similar features with adult livers, they aren’t perfect and our team still has work to do. For example, we still need to improve the capacity of the liver tissue to metabolize a variety of drugs. We also need to make it safer and more efficacious for eventual application in humans.[Deep knowledge, daily. Sign up for The Conversation’s newsletter.]Our study demonstrates the ability of these lab livers to mature and develop a functional network of blood vessels in just two and a half weeks. We believe this approach can pave the path for the manufacture of other organs with vasculature via genetic programming. The liver organoids provide several key features of an adult human liver such as production of key blood proteins and regulation of bile – a chemical important for digestion of food. When we implanted the lab-grown liver tissues into mice suffering from liver disease, it increased the life span. We named our organoids “designer organoids,” as they are generated via a genetic design. This article is republished from The Conversation, a nonprofit news site dedicated to sharing ideas from academic experts. It was written by: Mo Ebrahimkhani, University of Pittsburgh. Read more: * Brain organoids help neuroscientists understand brain development, but aren’t perfect matches for real brains * Why are scientists trying to manufacture organs in space?Mo Ebrahimkhani receives funding from National Institute of Health, University of Pittsburgh and Arizona Biomedical Research Council.

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