Interactions between RNA and proteins are the cornerstone of many important biological processes from transcription and translation to gene regulation, yet little is known about the ancient origin of said interactions. We hypothesized that peptide amyloids played a role in the origin of life and that their repetitive structure lends itself to building interfaces with other polymers through avidity. Here, we report that short RNA with a minimum length of three nucleotides binds in a sequence-dependent manner to peptide amyloids. The 3′–5′ linked RNA backbone appears to be well-suited to support these interactions, with the phosphodiester backbone and nucleobases both contributing to the affinity. Sequence-specific RNA–peptide interactions of the kind identified here may provide a path to understanding one of the great mysteries rooted in the origin of life: the origin of the genetic code.
The purpose of the attention schema theory is to explain how an information-processing device, the brain, arrives at the claim that it possesses a non-physical, subjective awareness and assigns a high degree of certainty to that extraordinary claim. The theory does not address how the brain might actually possess a non-physical essence. It is not a theory that deals in the non-physical. It is about the computations that cause a machine to make a claim and to assign a high degree of certainty to the claim. The theory is offered as a possible starting point for building artificial consciousness. Given current technology, it should be possible to build a machine that contains a rich internal model of what consciousness is, attributes that property of consciousness to itself and to the people it interacts with, and uses that attribution to make predictions about human behavior. Such a machine would “believe” it is conscious and act like it is conscious, in the same sense that the human machine believes and acts.
This article is part of a special issue on consciousness in humanoid robots. The purpose of this article is to summarize the attention schema theory (AST) of consciousness for those in the engineering or artificial intelligence community who may not have encountered previous papers on the topic, which tended to be in psychology and neuroscience journals. The central claim of this article is that AST is mechanistic, demystifies consciousness and can potentially provide a foundation on which artificial consciousness could be engineered. The theory has been summarized in detail in other articles (e.g., Graziano and Kastner, 2011; Webb and Graziano, 2015) and has been described in depth in a book (Graziano, 2013). The goal here is to briefly introduce the theory to a potentially new audience and to emphasize its possible use for engineering artificial consciousness.
The AST was developed beginning in 2010, drawing on basic research in neuroscience, psychology, and especially on how the brain constructs models of the self (Graziano, 2010, 2013; Graziano and Kastner, 2011; Webb and Graziano, 2015). The main goal of this theory is to explain how the brain, a biological information processor, arrives at the claim that it possesses a non-physical, subjective awareness and assigns a high degree of certainty to that extraordinary claim. The theory does not address how the brain might actually possess a non-physical essence. It is not a theory that deals in the non-physical. It is about the computations that cause a machine to make a claim and to assign a high degree of certainty to the claim. The theory is in the realm of science and engineering.
Complexity of biological forms has fascinated humankind over the years. Different species of plants have different leaf shapes. Have you ever wondered why it is so? Why does this shape diversity exist? Plants can change their leaf shapes over time and space. But how?
Does the distinct shape of leaf forms play a significant role in energy optimization? In fact, the shape of leaves has a lot to do with adapting to their surrounding environment. How is the unfolding of shape related to the evolutionary process of nature? These intriguing questions have led us to focus on quantitative approaches to the complexity of plant leaves.
Quantifying leaf shapes using Euclidean shapes, such as circles, triangles, etc., are appropriate to only a few plant species. Therefore, various quantitative measures of leaf shapes have been developed with varying accuracy. But Is the shape of an object really its actual shape? Visual perception of definite shape or geometry of physical objects is only an abstraction.
CryocrastinationDescription: Biostasis techniques such as cryopreservation, which allow recently-living organisms to be stored indefinitely without deteriora…
Dr. Avshalom Cyrus Elitzur (Hebrew: אבשלום כורש אליצור; born 30 May 1957) is an Israeli physicist, philosopher and professor at Chapman University. He is also the founder of the Israeli Institute for Advanced Physics. He obtained his PhD under Yakir Aharanov. Elitzur became a household name among physicists for his collaboration with Lev Vaidman in formulating the “bomb-testing problem” in quantum mechanics, which has been validaded by two Nobel-prize-winning physicists. Elitzur’s work has sparked extensive discussions about the foundations of quantum mechanics and its interpretations, including the Copenhagen interpretation, many-worlds interpretation, and objective collapse models. His contributions have had a profound impact on both physics and philosophy, influencing debates about measurement, the role of observers, and the ontology of quantum states. Elitzur has also engaged in discussions about consciousness, the arrow of time, and other foundational topics, including a recent breakthrough in bio-thermodynamics and the “ski-lift” pathway.
Elitzur’s Google Scholar page: https://tinyurl.com/5n7a8hd6
Elitzur’s Wikipedia page: https://en.wikipedia.org/wiki/Avshalo…
IAI Article: https://iai.tv/articles/a-radical-new…
Powerpoint presentation: Pending.
A new study shows how quantum computing can be harnessed to discover new properties of polymer systems central to biology and material science.
The advent of quantum computing is opening previously unimaginable perspectives for solving problems deemed beyond the reach of conventional computers, from cryptography and pharmacology to the physical and chemical properties of molecules and materials. However, the computational capabilities of present-day quantum computers are still relatively limited. A newly published study in Science Advances fosters an unexpected alliance between the methods used in quantum and traditional computing.
The research team, formed by Cristian Micheletti and Francesco Slongo of SISSA in Trieste, Philipp Hauke of the University of Trento, and Pietro Faccioli of the University of Milano-Bicocca, used a mathematical approach called QUBO (from “Quadratic Unconstraint Binary Optimization”) that is ideally suited for specific quantum computers, called “quantum annealers.”
Over the past few decades, it has become quite obvious that humans are not the only living organisms with intelligence.
The story of intelligence you are about to experience goes back 13.8 billion years, back to the moment the universe was born: the Big Bang. It’s a story of time and space, matter and energy. It is a story of unfolding, It’s the story of how the very nature of the physical universe from its very inception led to the universe getting to know itself and eventually, to reflect.
Complexity, Evolution, and Intelligence is comprised of five parts, each corresponding to a movement in Dan Forrest’s “Requiem For The Living.” This composition was performed August 2, 2013 in Raleigh, NC by Bel Canto, conducted by Dr. Bill Young.
Join us on Patreon! https://www.patreon.com/MichaelLustgartenPhDDiscount Links: Green Tea: https://www.ochaandco.com/?ref=conqueragingTelomere, Epigenetic Te…