Lifeboat Foundation

Unique opportunity to sponsor research investigating an infectious cause and potential treatment for Alzheimer’s disease

In these financially difficult times many funding bodies have to prioritise projects based around long established hypotheses. Projects involving new avenues of investigation can receive very positive comments by scientific reviewers, yet are rarely funded, as they almost always appear risky compared with projects largely confirming or expanding existing ideas. Such conservative projects are almost guaranteed to produce useful data, though with modest impact. This situation can mean that research proposals with the potential to transform our understanding of a disease and offer new approaches to its treatment never reach the threshold for funding and are not implemented, even though the potential and quality of the science is acknowledged by reviewers and funding panel.

It appears that our work examining a viral cause for Alzheimer’s disease is in this category. Despite our publishing a large number of potentially very exciting papers on this topic, and despite our research projects being reviewed favourably by scientific referees, few funding panels are prepared to commit resources to fund our work, as by doing so they deny funding to other more straightforward, very low risk projects.

We are therefore actively seeking sponsorship for several projects of varying costs to investigate the interaction of virus and specific genetic factor, the pathways of viral damage in the brain, and the effects of antiviral agents. All the projects would provide significant evidence strengthening the case for trialling antiviral agents in Alzheimer’s disease.

Antiviral agents would inhibit a likely major cause of the disease in contrast to current treatments, which merely inhibit the symptoms.

If any Lifeboat member knows of a company or individual that would be interested in sponsoring some of our research on Alzheimer’s disease then please contact me for further details.

Ruth Itzhaki

Continue reading “Unique opportunity to sponsor research investigating an infectious cause and potential treatment for Alzheimer’s disease” »

It will probably come as a surprise to those who are not well acquainted with the life and work of Alan Turing that in addition to his renowned pioneering work in computer science and mathematics, he also helped to lay the groundwork in the field of mathematical biology(1). Why would a renowned mathematician and computer scientist find himself drawn to the biosciences?

Interestingly, it appears that Turing’s fascination with this sub-discipline of biology most probably stemmed from the same source as the one that inspired his better known research: at that time all of these fields of knowledge were in a state of flux and development, and all posed challenging fundamental questions. Furthermore, in each of the three disciplines that engaged his interest, the matters to which he applied his uniquely creative vision were directly connected to central questions underlying these disciplines, and indeed to deeper and broader philosophical questions into the nature of humanity, intelligence and the role played by evolution in shaping who we are and how we shape our world.

Central to Turing’s biological work was his interest in mechanisms that shape the development of form and pattern in autonomous biological systems, and which underlie the patterns we see in nature (2), from animal coat markings to leaf arrangement patterns on plant stems (phyllotaxis). This topic of research, which he named “morphogenesis,” (3) had not been previously studied with modeling tools. This was a knowledge gap that beckoned Turing; particularly as such methods of research came naturally to him.

In addition to the diverse reasons that attracted him to the field of pattern formation, a major ulterior motive for his research had to do with a contentious subject which, astonishingly, is still highly controversial in some countries to this day. In studying pattern formation he was seeking to help invalidate the “argument from design” (4) concept, which we know today as the hypothesis of “Intelligent Design.”

Continue reading “Alan Turing: Biology, Evolution and Artificial Intelligence” »

Here’s a story that should concern anyone wanting to believe that the military has a complete and accurate inventory of chemical and biological warfare materials.

“An inventory of deadly germs and toxins at an Army biodefense lab in Frederick found more than 9,200 vials of material that was unaccounted for in laboratory records, Fort Detrick officials said Wednesday. The 13 percent overage mainly reflects stocks left behind in freezers by researchers who retired or left Fort Detrick since the biological warfare defense program was established there in 1943, said Col. Mark Kortepeter, deputy commander of the U.S. Army Medical Research Institute of Infectious Diseases.”

The rest of the story appears here:
http://abcnews.go.com/Health/wireStory?id=7863828

Given that “The material was in tiny, 1mm vials that could easily be overlooked,” and included serum from Korean hemorrhagic fever patients, the lack of adequate inventory controls to this point creates the impression that any number of these vials could be outside their lab. Of course, they assure us they have it all under control. Which will be cold comfort if we don’t have a lifeboat.

It sounds like cryonics is working, at least for microbes. But could any humans now alive have resistance to ancient organisms?

Rational Review carried a link to this story:

http://www.foxnews.com/story/0,2933,526460,00.html

“After more than 120,000 years trapped beneath a block of ice in Greenland, a tiny microbe has awoken. … The new bacteria species was found nearly 2 miles (3 km) beneath a Greenland glacier, where temperatures can dip well below freezing, pressure soars, and food and oxygen are scarce. ‘We don’t know what state they were in,’ said study team member Jean Brenchley of Pennsylvania State University. ‘They could’ve been dormant, or they could’ve been slowly metabolizing, but we don’t know for sure.’”

It is yet another interesting possibility against which humans should prepare to protect ourselves. Where is our Lifeboat?

U.S. News and World Report — May 12, 2009, by KEVIN McGILL

BATON ROUGE, La.—Combining human and animal cells to create what are sometimes called “human-animal hybrids” would be a crime in Louisiana, punishable by up to 10 years in prison, under legislation approved Tuesday by a state Senate panel.

Scientific researchers in some areas have tried to create human embryonic stem cells, which scientists say could be used to develop treatment for a variety of human ailments, by placing human DNA into animal cells. But such practices are controversial for a number of reasons.

Continue reading “Dr. Moreau outlawed in LA — Panel Votes to Outlaw Human-Animal Hybrids” »

(Crossposted on the blog of Starship Reckless)

Continue reading “Forever Young” »

May 2: Many U.S. emergency rooms and hospitals crammed with people… ”Walking well” flood hospitals… Clinics double their traffic in major cities … ER rooms turn away EMT cases. — CNN

Update May 4: Confirmed cases of H1N1 virus now at 985 in 20 countries (Mexico: 590, 25 deaths) — WHO. In U.S.: 245 confirmed U.S. cases in 35 states. — CDC.

“We might be entering an Age of Pandemics… a broad array of dangerous emerging 21st-century diseases, man-made or natural, brand-new or old, newly resistant to our current vaccines and antiviral drugs…. Martin Rees bet $1,000 that bioterror or bioerror would unleash a catastrophic event claiming one million lives in the next two decades…. Why? Less forest, more contact with animals… more meat eating (Africans last year consumed nearly 700 million wild animals… numbers of chickens raised for food in China have increased 1,000-fold over the past few decades)… farmers cut down jungle, creating deforested areas that once served as barriers to the zoonotic viruses…” — Larry Brilliant, Wall Street Journal

About

(Crossposted on the blog of Starship Reckless)

Working feverishly on the bench, I’ve had little time to closely track the ongoing spat between Dawkins and Nisbet. Others have dissected this conflict and its ramifications in great detail. What I want to discuss is whether scientists can or should represent their fields to non-scientists.

There is more than a dollop of truth in the Hollywood cliché of the tongue-tied scientist. Nevertheless, scientists can explain at least their own domain of expertise just fine, even become major popular voices (Sagan, Hawkin, Gould — and, yes, Dawkins; all white Anglo men, granted, but at least it means they have fewer gatekeepers questioning their legitimacy). Most scientists don’t speak up because they’re clocking infernally long hours doing first-hand science and/or training successors, rather than trying to become middle(wo)men for their disciplines.

Continue reading “On Being Bitten to Death by Ducks” »