The study, which is set to begin in the third quarter of 2025, will be a randomized, double-blind, placebo-controlled trial involving 40 stroke patients in Europe.
Dr. Nardai, a leading cerebrovascular disease specialist, is currently the Head of the Department of Neurointervention at Semmelweis University in Budapest, Hungary. He previously led a preclinical study published in Experimental Neurology in May 2020, which demonstrated that rats treated with sub-hallucinogenic doses of DMT showed near-complete motor function recovery and smaller infarct volumes compared to untreated control groups. This research provided the basis for Algernon’s clinical investigation into DMT as a potential neuroprotective agent for stroke recovery.
“The primary endpoint of the planned Phase 2a study will be safety,” said Dr. Nardai in the news release. “However, stroke clinicians worldwide will also be watching for positive signals regarding lesion volume, biomarkers, motor function, cognitive function, depression, and mortality.””
Algernon Pharmaceuticals Inc. (AGN: CSE; AGNPF: OTCQB; AGW0:XFRA) subsidiary Algernon NeuroScience has appointed Dr. Sandor Nardai as Principal Investigator for its upcoming Phase 2a DMT stroke study. Find out how this trial could reshape stroke recovery research.
When the Empire State Building was constructed, its 102 stories rose above midtown one piece at a time, with each individual element combining to become, for 40 years, the world’s tallest building. Uptown at Columbia, Oleg Gang and his chemical engineering lab aren’t building Art Deco architecture; their landmarks are incredibly small devices built from nanoscopic building blocks that arrange themselves.
“We can now build the complexly prescribed 3D organizations from self-assembled nanocomponents, a kind of nanoscale version of the Empire State Building,” said Gang, professor of chemical engineering and of applied physics and materials science at Columbia Engineering and leader of the Center for Functional Nanomaterials’ Soft and Bio Nanomaterials Group at Brookhaven National Laboratory.
“The capabilities to manufacture 3D nanoscale materials by design are critical for many emerging applications, ranging from light manipulation to neuromorphic computing, and from catalytic materials to biomolecular scaffolds and reactors,” said Gang.
If measured from beginning to end, the DNA in our cells is too long to fit into the cell’s nucleus, explaining why it must be constantly folded and packaged. When it is time for cell division, and the genetic information needs to be passed on to the next generation, DNA must be packed particularly tightly, or else serious consequences for a cell’s viability might ensue.
The drugs, sutezolid and delpazolid, have demonstrated strong antimicrobial activity and a notably better safety profile compared to linezolid, with the potential to replace this current cornerstone in the treatment of drug-resistant TB.
The findings were published in two articles in The Lancet Infectious Diseases. Research partners in Europe included Radboud University Medical Center in the Netherlands and the German Center for Infection Research (DZIF), Munich, the Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, the Center for International Health at LMU University Hospital and Helmholtz Munich.
The AAN’s AI chatbot toolkit provides practical guidance on utilizing AI-powered chatbots to enhance patient access to neurological care, including implementation strategies, safety considerations, and real-world applications.
Discover how MitoQ reverses vascular aging by 15–20 years! Chief Scientific Officer Dr. Mitchell reveals research on mitochondrial health, showing 42% improvement in blood flow and superior results vs CoQ10 for longevity. Some links are affiliate links so we will earn a commission when they are used to purchase products.
If you would like to support our channel please consider joining our Patreon / modernhealthspan. MitoQ https://tinyurl.com/5n93fm3f MitoQ Pure https://tinyurl.com/3hxy9s7x. Stemregen 15% discount Code MODERN https://tinyurl.com/45z968yr (Only available in the US) AX3 Life Astaxanthin 20% discount code MODERN20 https://tinyurl.com/2t3w26nw. All Muse devices 15% discount code MODERN https://choosemuse.com/MODERN Renue By Science 10% discount code MHS: https://tinyurl.com/bdew4bfs. NMN Powder https://tinyurl.com/syc7rwkh. DoNotAge 10% discount code MHS https://tinyurl.com/6dbvhv87 D3/K2 https://tinyurl.com/528z26b7 NMN https://tinyurl.com/wyzj2f3d. n1o1 Nitric Oxide 10% discount with code Modern https://tidd.ly/3IczGRW 15% off with code PRIME15 until July 12 n1o1 Nitric Oxide Lozenges https://tidd.ly/4eaJTdw. Age-Defiance Face Cream https://tidd.ly/4eaJTdw. Wellness Extract 10% discount Code MODERNWE Geranylgeraniol Essential http://wellnessextract.com/RICHARDWE Delta Gold Vit E Oxford Healthspan Spermidine 15% Code MHS Original https://tinyurl.com/hrxfnzpn, Gluten Free https://tinyurl.com/2s39pkzv. Nuchido Time+ 20% discount of first purchase with code MODERN20 https://nuchido.com/MODERN Pendulum 20% Discount Code HEALTHSPAN Akkermansia https://pendulumtherapeutics.sjv.io/b… Daily https://pendulumtherapeutics.sjv.io/N… OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/ OneSkin 15% Discount: Code MODERN OS-01 Face https://oneskin.pxf.io/Z6Yg0K In this comprehensive interview, Dr. Mitchell, Chief Scientific Officer at MitoQ, breaks down the revolutionary science behind mitochondrial-targeted antioxidants and their impact on aging and disease prevention. *Key Topics Covered:* • How MitoQ delivers 90% bioavailability to mitochondria vs 10% for regular CoQ10 • Clinical study showing 42% improvement in flow-mediated dilation (vascular function) • Why mitochondrial dysfunction is the root cause of aging diseases • Exercise performance benefits: improved VO2 max, peak power, and recovery • Brain health and cognitive function improvements • Cardiovascular benefits: reduced oxidized LDL, improved artery flexibility • Immune system support and inflammation reduction • Diabetes prevention through improved glucose metabolism • Proper dosing protocols and supplement combinations *Research Highlights:* ✓ 25+ clinical studies and 800+ research papers ✓ Reverses vascular aging by 15–20 years according to leading researcher Doug Seals ✓ Professional cyclists and elite athletes using MitoQ for performance ✓ Ongoing trials for frailty, cognitive function, and neurovascular health ✓ 300+ independent researchers studying MitoQ applications Learn why targeting mitochondria may be the key to preventing age-related diseases and optimizing healthspan. Discover the science-backed approach to cellular energy and antioxidant protection that’s changing how we think about aging. ⏲️Chapters 0:00 The problem with mitochondria 3:34 How Mitochondria Dysfunction Occurs with Aging 5:43 Natural Protective Mechanisms and CoQ10 7:38 The Invention of MitoQ — Superior Mitochondrial Targeting 11:15 How MitoQ Differs from CoQ10 13:31 MitoQ vs CoQ10 — Research Comparisons 17:52 Cardiovascular Benefits and Flow-Mediated Dilation 23:32 Heart Muscle Function and Immune System Effects 28:16 Exercise Performance and V2 Max Improvements 32:04 Research Funding and Collaborative Programs 36:11 Diabetes Prevention and Glucose Metabolism 39:02 Brain Health and Cognitive Benefits 44:23 Dosing Protocol and Administration Guidelines 48:04 Supplement Combinations and Future Directions 🌐Links in this video MitoQ Home page https://www.mitoq.com/ Mitochondrial Collaborative Research Program https://www.mcrp.dev/ *************************************** Health claims Disclosure: Information provided on this video is not a substitute for direct, individual medical treatment or advice. Please consult with your doctor first. Products or services mentioned in this video are not a recommendation. Audio Copyright Disclaimer Please note that we have full authorization to the music that we used in our videos as they were created using the service WeVideo which provides the rights to the music. The rights are detailed in the terms of use that can be reviewed here https://www.wevideo.com/terms-of-use and any following inquiries should be addressed to [email protected]. ************************************************ #MitoQ #Mitochondria #Longevity. Metabolic Daily https://pendulumtherapeutics.sjv.io/N… OmegaQuant 5% discount Code MODERN https://omegaquant.com/shop/ OneSkin 15% Discount: Code MODERN OS-01 Face https://oneskin.pxf.io/Z6Yg0K
In this comprehensive interview, Dr. Mitchell, Chief Scientific Officer at MitoQ, breaks down the revolutionary science behind mitochondrial-targeted antioxidants and their impact on aging and disease prevention.
*Key Topics Covered:* • How MitoQ delivers 90% bioavailability to mitochondria vs 10% for regular CoQ10 • Clinical study showing 42% improvement in flow-mediated dilation (vascular function) • Why mitochondrial dysfunction is the root cause of aging diseases. • Exercise performance benefits: improved VO2 max, peak power, and recovery. • Brain health and cognitive function improvements. • Cardiovascular benefits: reduced oxidized LDL, improved artery flexibility. • Immune system support and inflammation reduction. • Diabetes prevention through improved glucose metabolism. • Proper dosing protocols and supplement combinations.
*Research Highlights:* ✓ 25+ clinical studies and 800+ research papers. ✓ Reverses vascular aging by 15–20 years according to leading researcher Doug Seals. ✓ Professional cyclists and elite athletes using MitoQ for performance. ✓ Ongoing trials for frailty, cognitive function, and neurovascular health. ✓ 300+ independent researchers studying MitoQ applications.
Learn why targeting mitochondria may be the key to preventing age-related diseases and optimizing healthspan. Discover the science-backed approach to cellular energy and antioxidant protection that’s changing how we think about aging.
Serendipitous discovery of djerfisherite in Ryugu grain challenges current paradigm of the nature of primitive asteroids. A surprising discovery from a tiny grain of asteroid Ryugu has rocked scientists’ understanding of how our Solar System evolved. Researchers found djerfisherite—a mineral typically born in scorching, chemically reduced conditions and never before seen in Ryugu-like meteorites—inside a sample returned by Japan’s Hayabusa2 mission. Its presence suggests either Ryugu once experienced unexpectedly high temperatures or that exotic materials from other parts of the solar system somehow made their way into its formation. Like discovering a palm tree fossil in Arctic ice, this rare find challenges everything we thought we knew about primitive asteroids and the early mixing of planetary ingredients.
The pristine samples from asteroid Ryugu returned by the Hayabusa2 mission on December 6, 2020, have been vital to improving our understanding of primitive asteroids and the formation of the Solar System. The C-type asteroid Ryugu is composed of rocks similar to meteorites called CI chondrites, which contain relatively high amounts of carbon, and have undergone extensive aqueous alteration in their past.
A research team at Hiroshima University discovered the presence of the mineral djerfisherite, a potassium-containing iron-nickel sulfide, in a Ryugu grain. The presence of this mineral is wholly unexpected, as djerfisherite does not form under the conditions Ryugu is believed to have been exposed to over its existence. The findings were published on May 28, 2025, in the journal Meteoritics & Planetary Science.
From the mud, straw, and gypsum mixtures of ancient Egypt’s monumental pyramids to the sophisticated underwater material employed by Roman engineers in iconic structures like the Pantheon, concrete has long symbolized civilization’s resilience and ingenuity.
Artificial intelligence (AI) can be made more sustainable by making practical changes, such as reducing the number of decimal places used in AI models, shortening responses, and using smaller AI models, according to research from UCL published in a new UNESCO report.
In recent years, the use of generative AI has expanded rapidly, with large language models (LLMs) developed by companies such as OpenAI, Meta and Google becoming household names. For example, OpenAI’s ChatGPT service, powered by the GPT-4 LLM, receives about 1 billion queries each day.
Each generation of LLMs has become more sophisticated than the last, better able to perform tasks like text generation or knowledge retrieval. This has led to a vast and increasing demand on resources such as electricity and water, which are needed to run the data centers where these AI models are trained and deployed.
A major hurdle to curing HIV is the persistence of integrated proviruses in resting CD4+ T cells that remain in a transcriptionally silent, latent state. One strategy to eradicate latent HIV is to activate viral transcription, followed by elimination of infected cells through virus-mediated cytotoxicity or immune-mediated clearance. We hypothesised that mRNA-lipid nanoparticle (LNP) technology would provide an opportunity to deliver mRNA encoding proteins able to reverse HIV latency in resting CD4+ T cells. Here we develop an LNP formulation (LNP X) with unprecedented potency to deliver mRNA to hard-to-transfect resting CD4+ T cells in the absence of cellular toxicity or activation. Encapsulating an mRNA encoding the HIV Tat protein, an activator of HIV transcription, LNP X enhances HIV transcription in ex vivo CD4+ T cells from people living with HIV. LNP X further enables the delivery of clustered regularly interspaced short palindromic repeats (CRISPR) activation machinery to modulate both viral and host gene transcription. These findings offer potential for the development of a range of nucleic acid-based T cell therapeutics.
Resting T cells are difficult to manipulate, and are a reservoir for latent HIV. Here, the authors develop a lipid nanoparticle formulation with the ability to transfect resting primary human T cells, enabling delivery of mRNAs that result in reactivation of latent HIV. This could help development of HIV cure strategies.
