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Matuskey, D., Yang, Y., Naganawa, M. et al. ¹¹ C-UCB-J PET imaging is consistent with lower synaptic density in autistic adults. Mol Psychiatry (2024). https://doi.org/10.1038/s41380-024-02776-2

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Generating water from thin air can solve water woes for remote communities and arid regions but the technology is too expensive for them to afford it.

Solar-driven atmospheric water extraction (SAWE) systems have the potential to address the ongoing freshwater scarcity, but they can only produce water intermittently. Here the authors developed a SAWE system with optimised architecture to achieve continuous freshwater production under sunlight.

Large-scale protein and gene profiling have massively expanded the landscape of cancer-associated proteins and gene mutations, but it has been difficult to discern whether they play an active role in the disease or are innocent bystanders.

In a study published in Nature Cancer, researchers at Baylor College of Medicine revealed a powerful and unbiased machine learning-based approach called FunMap for assessing the role of cancer-associated mutations and understudied proteins, with broad implications for advancing cancer biology and informing therapeutic strategies.

“Gaining functional information on the genes and proteins associated with cancer is an important step toward better understanding the disease and identifying potential therapeutic targets,” said corresponding author Dr. Bing Zhang, professor of molecular and human genetics and part of the Lester and Sue Smith Breast Center at Baylor.

The newly found ORC, designated ORC J0219–0505, was discovered in data from the MIGHTEE survey conducted by the MeerKAT radio telescope located in the Meerkat National Park in the Northern Cape of South Africa. The 371,600 light-year-wide ORC seems to be associated with the elliptical galaxy WISEA J021912.43–050501.8. It has features that seem to set it apart from other ORCs, including the fact that it appears fainter and that details of its structure reveal it leans to one side.

“Odd Radio Circles: Circles of radio emission found around distant galaxies that we still don’t understand,” lead researcher and Western Sydney University astronomer Ray Norris told Space.com. “It’s a completely unexpected discovery, not predicted by the physics we already know, and therefore revealing a gap in our knowledge.

So we hope these will tell us something new about how galaxies form and interact.

Cells in the immune system don’t always fight; they often rest and wait for threats, like viruses or bacteria. When such threats emerge, the cells activate to defend the body. This delicate balance between rest and activation is crucial to our health—immune cells must be poised for activation to protect against threats, but if they’re overly active, autoimmune diseases can result.

But what controls this important balance?

In a new study published in Nature, scientists from Gladstone Institutes and UC San Francisco (UCSF) focused on T cells—which serve a vital role in the immune system—and pinpointed how a network of different proteins controls rest and activation.

The arrival of Paxlovid in December 2021 marked another turning point in the COVID-19 pandemic—an effective antiviral that has since successfully treated millions. But like many antivirals before it, scientists know that at some point, Paxlovid is likely to lose some efficacy due to drug resistance. Researchers working to stay ahead of such emerging threats have now identified a wholly new way to treat SARS-CoV-2 infections—work that may have even broader implications.

In fact, a new study by the Tuschl laboratory introduces a proof-of-concept for a novel class of antivirals that would target a type of enzyme essential not just to SARS, but also many RNA viruses, including Ebola and dengue, as well as cytosolic-replicating DNA viruses, including Pox viruses. The findings may pave the way for a faster and more robust response to future pandemics.

“Nobody has found a way to inhibit this enzyme before,” says Thomas Tuschl, the F. M. Al Akl and Margaret Al Akl professor at Rockefeller. “Our work establishes cap methyl transferase enzymes as therapeutic targets and opens the door to many more antiviral developments against pathogens that until now we’ve had only limited tools to fight.”

The results of a clinical trial into a new malaria vaccine candidate (RH5.1/Matrix-MTM) show it is well-tolerated and offers effective protection against the blood-stage of the disease—the first inoculation to do so.

Malaria, caused by Plasmodium falciparum parasites, is a leading cause of death in children under five in many parts of Africa. Blood-stage malaria —when the parasite infects red blood cells —causes symptoms of the disease like fever and chills, and can lead to severe, life-threatening complications such as anemia and organ failure.

The study has been run by scientists at the University of Oxford in collaboration with the Clinical Research Unit of Nanoro (CRUN) at the Institut de Recherche en Sciences de la Santé (IRSS) in Burkina Faso, the London School of Hygiene and Tropical Medicine (LSHTM) in the U.K. and the National Institute of Health (NIH) in the U.S., with support from other partners including the Serum Institute of India Pvt. Ltd, Novavax and ExpreS2ion Biotechnologies ApS.

Researchers at the University of Copenhagen have demonstrated that the brain’s ability to learn certain skills can be significantly enhanced if both the brain and nervous system are primed by carefully-calibrated, precisely-timed electrical and magnetic stimulations. This new research has the potential to open entirely new perspectives in rehabilitation and possibly elite sports.

Scientists meticulously calculate the process. First, electricity is delivered to a nerve in the forearm of a test subject. Milliseconds later, magnetic stimulation is applied to the motor area of their brain using a coil placed on their head. The immediate effect is visible as small, involuntary twitches in the subject’s hand. Ten seconds later, the process is repeated.

While this may evoke images of Dr. Frankenstein at work, the reality is that of pioneering research into the brain’s capacity to learn that could unlock new understandings of brain function and provide new avenues for motor training and rehabilitation. The young, healthy test subjects reportedly felt almost nothing during the process, but displayed enhanced benefits from their motor training session thereafter.