Lifeboat Foundation

A novel breakthrough, leveraging CRISPR gene-editing technology, is revolutionizing how scientists study sEVs. This innovative approach, known as CIBER (CRISPR-assisted individually barcoded sEV-based release regulator), enables researchers to investigate thousands of genes simultaneously.

By tagging sEVs with unique RNA “barcodes,” CIBER offers unparalleled insights into the molecular processes regulating sEV release, setting the stage for advancements in biotechnology and disease treatment.

Extracellular vesicles, which include sEVs, are small, membrane-enclosed particles released by cells into their surroundings. Their size, origin, and cargo determine their classification. sEVs, typically 30–200 nanometers in diameter, are among the smallest but most intriguing members of this group. These vesicles transport biomolecules—such as RNA, proteins, and lipids —between cells, acting as communication messengers.

One class at Indiana University Indianapolis is doing its part to help out.

“What that large switch does is it just allows the child to activate it either with a whole hand or even a light touch,” Tiffany Stead, Occupational Therapist and Adjunct professor at IUI, said.

Each student rewired the traditional toy and added a larger 3D-printed button.

A new study published in the journal Nature reports results of the first-in-human phase 1 clinical trials of a novel immunotherapy approach for solid tumors expressing glypican-3 (GPC3). Researchers at Baylor College of Medicine and Texas Children’s Cancer Center led the study, which tested chimeric antigen receptor (CAR) T cells enhanced with the protein interleukin-15 (IL-15).

CAR T cells have shown limited efficacy in patients with solid cancers, despite dramatic success in some hematologic malignancies. Preclinical studies showed that the addition of IL-15, which helps T cells survive and multiply, could improve the performance of CAR T cell-based immunotherapies.

In these trials, researchers tested GPC3-specific CAR T cells co-expressing IL-15 in adults with hepatocellular carcinoma (HCC) (NCT02905188) and children with GPC3 expressing solid tumors, including HCC (NCT02932956). The first patient cohorts received GPC3-CAR T cells alone. The GPC3-CAR T cells were found to be safe, with peak cell expansion at two-weeks post-infusion; however, no objective antitumor responses were observed.

Clay minerals are a major constituent of the Earth’s surface and are mainly found in the sediments of lakes, rivers and oceans. The properties of clay and claystone depend on how the tiny sediment particles are orientated. Using the European Synchrotron particle accelerator in Grenoble (France), a research team from the Martin Luther University Halle-Wittenberg (MLU) has succeeded for the first time in observing in detail how some of the processes work.

The study was published in the journal Communications Earth & Environment and provides researchers with insights into the structure and properties of sediments.

The formation of clay-rich sediments is difficult to study. “Sedimentation occurs, for example, on the hard-to-reach seafloor over a very long period of time. In addition, clay particles are only a few micrometers or less in size. As a result, conventional microscopy methods are not suitable for the observation of clay particles during sedimentation,” explains Dr. Rebecca Kühn, a geoscientist at MLU, lead researcher of the study.

The Feynman Lectures on Physics, Volume I: https://www.feynmanlectures.caltech.edu/I_toc.html.

“In this chapter, we shall discuss one of the most far-reaching generalizations of the human mind. While we are admiring the human mind, we should take some time off to stand in awe of a nature that could follow with such completeness and generality such an elegantly simple principle as the law of gravitation. What is this law of gravitation? ”

FELIX study results reveal obe-cel’s potential in relapsed B-cell ALL, achieving 77% remission with low severe toxicity, enhancing CAR T-cell therapy outcomes.

In a new Nature Communications study, scientists have developed a novel method for artificial cells to interact with their external environment without the need for complex modification processes.

This method could open new frontiers in tissue engineering, drug delivery, and cell processes.

Biological cells are protected by a membrane, made of phospholipids, which modulates interactions with the outside environment. Recreating this in artificial cells is challenging, requiring manual external modification of the membrane.

DEADLINE APPROACHING! The NEH program is accepting applications through Dec. 11, 2024. For more information, visit.

For organizations in areas affected by Hurricane Helene in FL, GA, SC, NC, VA and TN, optional prospectuses will be accepted until Oct 16th. The prospectus must use the Prospectus Template.

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When NASA’s Voyager 2 spacecraft flew by Uranus in 1986, it provided scientists’ first—and, so far, only—close glimpse of this strange, sideways-rotating outer planet. Alongside the discovery of new moons and rings, baffling new mysteries confronted scientists. The energized particles around the planet defied their understanding of how magnetic fields work to trap particle radiation, and Uranus earned a reputation as an outlier in our solar system.

Now, new research analyzing the data collected during that flyby 38 years ago has found that the source of that particular mystery is a cosmic coincidence. It turns out that in the days just before Voyager 2’s flyby, the planet had been affected by an unusual kind of space weather that squashed the planet’s magnetic field, dramatically compressing Uranus’s magnetosphere.

“If Voyager 2 had arrived just a few days earlier, it would have observed a completely different magnetosphere at Uranus,” said Jamie Jasinski of NASA’s Jet Propulsion Laboratory in Southern California and lead author of the new work published in Nature Astronomy. “The spacecraft saw Uranus in conditions that only occur about 4% of the time.”