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Feb 22, 2024

In deep reinforcement learning, a pruned network is a good network

Posted by in category: futurism

Join the discussion on this paper page.

Feb 22, 2024

Finding the Right Targets to Treat Biliary Tract Cancers

Posted by in categories: biotech/medical, satellites

Researchers are working on ways to improve the effectiveness of currently approved bile duct cancer, also called cholangiocarcinoma, treatments and finding early success in the development of more targeted therapies. Read more on the AACR Blog:

To overcome this issue, researchers are exploring next-generation FGFR inhibitors. During the 2024 American Society of Clinical Oncology (ASCO) Gastrointestinal Cancers Symposium in January 2024, phase II clinical trial results were announced for tinengotinib, a FGFR1-3 inhibitor that binds to FGFR in a way that blocks FGFR2 fusion and rearrangement, preventing the mutations that cause resistance to treatment. Of the patients in the trial whose tumors had developed resistance to a previous FGFR inhibitor, 37.5% demonstrated a partial response with tumor reductions ranging from 40.7% to 54.6%. A phase III trial for the drug candidate kicked off in December 2023.

Other next-generation FGFR inhibitors are in various stages of development, including RLY-4008 (phase I/II trial), erdafitinib (phase IIa), KIN-3248 (phase I/Ib), derazantinib (phase II), tasurgratinib (phase II), and HMPL-453 (phase II).

Continue reading “Finding the Right Targets to Treat Biliary Tract Cancers” »

Feb 22, 2024

A light touch: Changing the way we treat traumatic brain injury

Posted by in categories: biotech/medical, health, neuroscience

Contrary to popular perception, traumatic brain injury (TBI) is not the reserve of car accidents and punishing contact sports; it’s surprisingly common. Up to 50 million new cases of traumatic brain injury are registered each year worldwide. Notably, 80% of TBI occurs in low-to middle-income countries, and it is also the leading cause of death and disability in young adults. Overall, the global economic burden of TBI is estimated at 400 billion USD.

Minimising the devastating effects of TBI doesn’t rely solely on reducing the risk of an injury; it’s also essential to improve treatment after one has happened. For that, physiological real-time monitoring of vital signals is critical. One inventor has made it his mission to create devices that can do this accurately, easily, anywhere, and what’s more, they are also non-invasive.

Professor Arminas Ragauskas is a founder and director of the Health Telematics Science Institute at Kaunas University of Technology in Lithuania, which develops innovative industrial and physiological measurement and process monitoring technologies. He is particularly known for his work on non-invasive intracranial pressure and cerebral blood flow autoregulation measurement devices. He was also the national coordinator of the CENTER-TBI project, funded by the European Commission and the EU industry, with a budget of 40 million EUR, and focused European efforts to advance the care of patients with traumatic brain injury.

Feb 22, 2024

Universe’s brightest known object and fastest-growing black hole revealed

Posted by in category: cosmology

The universe’s brightest object is a quasar in a distant galaxy that’s powered by the fastest-growing black hole ever recorded, according to a new study.

Feb 22, 2024

Googol Gear #shorts

Posted by in category: futurism

#facts #uniquefacts #science #experiment

Feb 21, 2024

LongRoPE: Extending LLM Context Window Beyond 2 Million Tokens

Posted by in category: futurism

Microsoft presents LongRoPE

Extending LLM context window beyond 2 million tokens.

Join the discussion on this paper page.

Feb 21, 2024

ADHD linked to evolutionary success in ancient humans

Posted by in category: genetics

While current diagnostic definitions of attention-deficit hyperactivity disorder (ADHD) are relatively new, the general condition has been identified by clinicians under a variety of names for centuries. Recent genetic studies have revealed the condition to be highly heritable, meaning the majority of those with the condition have genetically inherited it from their parents.

Depending on diagnostic criteria, anywhere from two to 16% of children can be classified as having ADHD. In fact, increasing rates of diagnosis over recent years have led to some clinicians arguing the condition is overdiagnosed.

What is relatively clear, however, is that the behavioural characteristics that underpin ADHD have been genetically present in human populations for potentially quite a long time. And that has led some researchers to wonder what the condition’s evolutionary benefits could be.

Feb 21, 2024

Scientists Claim AI Breakthrough to Generate Boundless Clean Fusion Energy

Posted by in categories: nuclear energy, robotics/AI

Princeton researchers report that a new AI model has solved one of the major roadblocks to generating fusion energy.

Feb 21, 2024

Private US spacecraft enters orbit around the moon ahead of landing attempt

Posted by in category: space travel

A private U.S. lunar lander is in orbit around the moon, a day before it will attempt to land on the surface.

Feb 21, 2024

Ethical AI Discourses Introduction

Posted by in categories: futurism, robotics/AI

Image above shown at Conscious Life Expo 2024 (Ages of AI and Future of Life)

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