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Dec 9, 2023

Researchers discover new lipid nanoparticle that shows muscle-specific mRNA delivery, reduces off-target effects

Posted by in categories: biotech/medical, nanotechnology

A team of researchers based at the University of Toronto’s (U of T) Leslie Dan Faculty of Pharmacy has discovered a novel ionizable lipid nanoparticle that enables muscle-focused mRNA delivery while minimizing off-target delivery to other tissues. The team also showed that mRNA delivered by the lipid nanoparticles investigated in their study triggered potent cellular-level immune responses as a proof-of-concept melanoma cancer vaccine.

The study, led by Bowen Li, assistant professor, Leslie Dan Faculty of Pharmacy, U of T, was published this week in Proceedings of the National Academy of Sciences.

Called iso-A11B5C1, the new nanoparticle demonstrates exceptional mRNA delivery efficiency in muscle tissues while also minimizing unintended mRNA translation in organs such as the liver and spleen.

Dec 9, 2023

Genetic mutations that promote reproduction tend to shorten human lifespan, study shows

Posted by in categories: biotech/medical, genetics, life extension

A University of Michigan-led study based on a review of genetic and health information from more than 276,000 people finds strong support for a decades-old evolutionary theory that sought to explain aging and senescence.

In 1957, evolutionary biologist George Williams proposed that genetic mutations that contribute to aging could be favored by natural selection if they are advantageous early in life in promoting earlier reproduction or the production of more offspring. Williams was an assistant professor at Michigan State University at the time.

Williams’ idea, now known as the antagonistic pleiotropy theory of aging, remains the prevailing evolutionary explanation of senescence, the process of becoming old or aging. While the theory is supported by individual case studies, it has lacked unambiguous genome-wide evidence.

Dec 9, 2023

How a pathogenic bacterium uses molecular mimicry to compromise a cell’s protein building factory

Posted by in category: biotech/medical

The central dogma of molecular biology postulates that the information packets encoded within the molecules of deoxyribonucleic acid (DNA) are first transcribed into molecules of messenger ribonucleic acids (mRNAs), and then subsequently translated/decoded to generate molecules called proteins.

Proteins are essential biomolecules that are composed of multiple smaller subunits called amino acids. These amino acids are stitched together via peptide bonds and contribute to the shape, size and charge distribution that the protein, as a sum of its amino acid parts, eventually exhibits.

Continue reading “How a pathogenic bacterium uses molecular mimicry to compromise a cell’s protein building factory” »

Dec 9, 2023

Team reviews phosphine ligand-induced structural transformation of metal nanoclusters

Posted by in categories: biotech/medical, nanotechnology

A team of researchers has reviewed a unique method for reforming the structures of ultra-small nanomaterials. These nanomaterials, called metal nanoclusters, bridge the gap between the metal atom and the bulk metal, making them highly useful in both basic and applied research. Metal nanoclusters have the potential for wide-ranging applications in the biomedical fields.

The team’s review paper is published in the journal Polyoxometalates.

The team investigated the phosphine-LEIST reaction. This method shows advantages in nanoclusters’ structural modification and property modulation. “The method we reviewed is able to modulate the atomically precise structure of metal nanoclusters and regulate their corresponding performance,” said Man-Bo Li, a professor at Anhui University, China.

Dec 9, 2023

New Rule: Mr. Beast is Helping Wrong!

Posted by in category: robotics/AI

It’s the season of giving and Bill Maher calls out the haters who complain that YouTube celebrity Mr. Beast is only serving himself when helping others.

Dec 9, 2023

New Rule: Woke Capitalism

Posted by in category: futurism

There’s nothing wrong with not having an opinion on something. Especially if you don’t know what the f**k you’re talking about.

Dec 9, 2023

Mixtral: French start-up Mistral releases what is essentially a small GPT-4

Posted by in category: robotics/AI

French startup Mistral AI has released its new language model Mixtral 8x7B via a torrent link. Mixtral is a mixture-of-experts model, following an architecture that OpenAI is rumored to be using for GPT-4, but on a much larger scale.

There are no benchmarks, blog posts, or articles about the model yet, but Mistral-7B — the first version of Mistral AI — generally performed very well and was quickly adopted by the open-source community. Mistral is thought to have used the MegaBlocks MoE library for training. The Paris-based company was recently valued at nearly $2 billion.

Dec 9, 2023

Prioritizing Brain Health: Preventing Cognitive Decline

Posted by in categories: life extension, neuroscience

In this episode of the Lifespan podcast, Dr. David Sinclair and co-host Matthew LaPlante dissect the topic of brain aging. They explore evidence suggesting that the brain ages more slowly than other parts of the body and highlight how cognitive function is impacted by aging. Different interventions aimed at preserving brain health are also discussed, including a plant-based diet, exercise, metformin, NAD boosters, and sufficienh #Wellness #DavidSinclair #Longevity #BrainHealth #Healthspan

Dec 9, 2023

Stressors for Longevity: Exercise, Heat, Cold & More

Posted by in categories: biotech/medical, life extension

In Episode 3 of the Lifespan Podcast, Dr. David Sinclair and Matthew LaPlante dive deeply into the science of non-dietary interventions that mimic adversity and promote health. They begin by highlighting how different types of physical activity (i.e., low-intensity aerobic exercise, high-intensity aerobic exercise, and weight training) protect against age-related disease and enhance longevity. David and Matthew additionally highlight the latest evidence behind hyperbaric oxygen therapy, cold therapy, and heat therapy. As they discuss different adversity mimetics, they also explain how these interventions influence aging at the molecular and physiological levels.

Dec 9, 2023

Unlocking the Secrets of Lifespan with Dr. David Sinclair

Posted by in categories: genetics, life extension

Welcome to Lifespan with Dr. David Sinclair. Dr. David Sinclair is a professor of genetics and co-director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research.

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