When standardizing for age, the study found that incidence increased from 1.46 to 2.35 (EAPC = 1.42%), prevalence from 10.03 to 14.00 (EAPC = 1.09%), and YLD from 1.65 to 2.27 (EAPC = 1.05%) per 100,000 individuals globally.

The study further revealed a marked sex difference in PD’s demographic burden, finding that men were approximately 1.5 times more likely to develop EOPD than their female counterparts. Specifically, the study analyses estimated male prevalence at 16.74 per 100,000 versus 11.23 for females.

Geographically, middle and high-middle SDI zones were observed to experience the fastest EOPD growth rate, led by East Asia and Andean Latin America. At the national level, Peru, Bolivia, and Ecuador logged the highest age-standardized rates, while China and Norway showed some of the fastest national upward trends; China’s incidence EAPC was 2.55%.