https://doi.org/10.1172/JCI197923 Here, David A. Brenner & team discover the RNA-binding protein LARP6 as a master coordinator of hepatic stellate cell activation and fibrosis, using human tissue and liver spheroid models of MASH and MetALD.
The image shows collagen labeling (red) in human liver spheroids MASH model with LARP6-targeting ASO (DAPI, blue). Collagen labeling is decreased compared with MASH control.
11 Center for Epigenomics, UCSD, La Jolla, California, USA.
12 Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.
13 Department of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, Florida, USA.