https://doi.org/10.1172/JCI200062 Here, Tiffany C. Scharschmidt & team report on the early life window for immune tolerance using human samples, finding naïve CD4+ T cells in cord blood have distinct metabolic traits that enable their regulatory potential.

The schematic shows mass cytometry metabolic markers in their corresponding pathways.

Address correspondence to: Tiffany C. Scharschmidt, 1701 Divisadero Street, 3rd Floor, San Francisco, California 94,115, USA. Phone: 415.476.1696; Email: [email protected].