This imbalance results in dermal thinning, wrinkle formation, and loss of skin elasticity. Both intrinsic aging (chronological) and extrinsic aging (photoaging) contribute to collagen depletion. Studies have shown that UV-induced ROS accelerate collagen breakdown and inhibit new collagen synthesis, exacerbating visible signs of aging. ^[20]

Collagen is vital for skin firmness and elasticity. Aging, both intrinsic and extrinsic, leads to reduced collagen production and increased enzymatic degradation. Antiaging interventions such as retinoids, marine peptides, and nanoformulations aim to restore collagen levels and improve skin structure.

Understanding these cellular and molecular mechanisms provides the foundation for developing targeted antiaging interventions, ranging from holistic lifestyle modifications to advanced biomedical therapies.