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Abstract: In ProstateCancer, treatment resistance and disease progression can be promoted by androgen receptor splice variants

Here, Johann de Bono, Luke Gaughan & team identify the protein TRA2B as being key for the synthesis of AR-Vs.


1Newcastle University Centre for Cancer, Paul O’Gorman Building, Framlington Place, Newcastle upon Tyne, United Kingdom.

2The Institute for Cancer Research, London, United Kingdom.

3The Royal Marsden NHS Foundation Trust, London, United Kingdom.

4Newcastle University Bioinformatics Service Unit, Medical School, Newcastle University, Newcastle, United Kingdom.

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