https://doi.org/10.1172/JCI192928 Here, Xue-Zhong Yu & team identify Pim2 as a key negative regulator of CD8 T-cell antitumor immunity and validate it as a potential therapeutic target for enhancing cancer immunotherapy.

Electron microscopy images show visible autophagosomes in activated WT T cells, but not in Pim2-KO cells, supporting a model in which the PIM2 promotes T cell autophagy.

Address correspondence to: Xue-Zhong Yu or Yongxia Wu, Department of Microbiology and Immunology, Medical College of Wisconsin, 8,701 Watertown Plank Road, Milwaukee, Wisconsin, 53,226, USA. Phone: 414.955.8187; Email: [email protected] (XZY). Phone: 414.955.8148; Email: [email protected] (YW).