New from Wei-Yao Chin, Shi-Chuen Miaw et al. (國立臺灣大學 National Taiwan University): macrophage Ak4 is vital for defense against bacteria. Ak4 fuels mtDNA synthesis ➡️ boosts mtROS production ➡️ kills pathogens. Loss of Ak4 leads to severe susceptibility.

Chin et al. discovered that macrophage-specific Ak4 regulates mtDNA synthesis, through which it controls mitochondrial biogenesis and mtROS levels and, sub.