However, the pathogenic contribution of PTPN11 mutations has been unclear.

John C. Byrd & team reveal PTPN11 mutations in AML can be early events in the clonal evolution of disease development and are associated with variably differentiated myeloid cells, based on human and murine studies:

The figure shows lower survival of the Npm1cA/Ptpn11E76K mouse model.

¹Medical Scientist Training Program, The Ohio State University, Columbus, Ohio, USA.

²Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio, USA.

³Division of Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital, Cincinnati, Ohio, USA.