Here, Wen-Xing Ding find alterations in mitochondrial dynamics and the accumulation of large mitochondria contribute to liver tumor development in mice: https://doi.org/10.1172/JCI194441 # MASH
The EM image shows liver cells with megamitochondria (arrows) from mice lacking liver-specific dynamin-related protein 1 (Dnm1).
1Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, USA.
2Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences and.
3Department of Pharmacology, School of Medicine, Wayne State University, Detroit, Michigan, USA.