In Science last year, researchers presented a method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells.

The approach showed rapid and sustained immune reprogramming in preclinical models, highlighting its promise for treating cancer and autoimmune diseases.

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Lipid nanoparticles are designed to generate therapeutic T cells inside living animal models.

Vivek Peche and Stephen Gottschalk Authors Info & Affiliations

Science

Vol 388, Issue 6753