John D. Crispino & team suggest that suppression of the substrate receptor FBXO11 causes inefficient ubiquitylation of NPM1, contributing to MDS pathogenesis:
The image shows stronger correlation of NPM1 (magenta) and FBXO11 (green) in the nucleoplasm of CD34+ cells compared with the nucleolar subcompartment.
10 Cyrus Tang Medical Institute, Suzhou Medical Collage, Soochow University, Suzhou, Jiangsu Province, China.
11 Department of Pathology, Northwestern University, Chicago, Illinois, USA.
12 Department of Pathology, Division of Comparative Pathology, St. Jude Children’s Research Hospital, Memphis, Tennessee, USA.