Clinically suspected neurodegeneration in histiocytic neoplasms as causes of neurologic decline: a retrospective study.

ObjectivesThe aim of this study was to evaluate the causes of suspected neurodegeneration in adults with histiocytic neoplasms. MethodsPatients with histiocytic neoplasms were identified. Inclusion criteria were diagnosis of histiocytic neoplasm; the treating hematologist suspected neurodegeneration; and patients age 18 years or older. Active CNS histiocytic neoplasm was defined as new or enlarging T2 lesions, or gadolinium enhancing lesions on MRI.