Alcohol is notoriously bad for health, and a recent study might add “long-term effects on brain health” to the growing list of ways drinking can cause harm.

The research, led by scientists at the University of São Paulo in Brazil, investigated the impact of regular drinking by examining brain autopsy data from 1,781 individuals, correlating findings with their reported drinking habits.

After adjusting for sociodemographic and clinical variables, like smoking and physical activity, the team found that the heaviest drinkers had a 133 percent higher risk of developing vascular brain lesions compared to non-drinkers.