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Human skeletal development and regeneration are shaped by functional diversity of stem cells across skeletal sites

Ambrosi and colleagues profile human skeletal stem cells (hSSCs) across ten fetal skeletal sites and from patients throughout adulthood, identifying, mapping, and functionally testing four distinct hSSC subtypes. Skeletal aging and disease are characterized by a dominant fibrogenic hSSC variant, but targeting defined gene regulatory networks reinstates functional hSSC diversity.

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