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QRICH1 mediates an intracellular checkpoint for CD8+ T cell activation via the CARD11 signalosome

Scientists demonstrate that the protein QRICH1 limits T cell activation by inhibiting CARD11 signaling to NFkB after T cell receptor stimulation.

Read more in Science Immunology.


QRICH1 negatively regulates CD8+ T cell activation by fine-tuning CARD11 signaling to NF-κB.

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