Does autoimmunity underlie minimal change disease?

Tobias B. Huber, Nicola M. Tomas & team report a direct pathogenic role of anti-nephrin autoantibodies in the development of podocytopathy with a minimal change disease phenotype:

The electron microscopy image shows moderate podocyte foot process effacement (without electron-dense deposits) in the anti-nephrin rabbit.

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Address correspondence to: Tobias B. Huber or Nicola M. Tomas, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany. Phone: 49.40.7410.53908; Email: [email protected] (TBH); [email protected] (NMT).