Researchers at the Sainsbury Wellcome Center (SWC) at UCL have unveiled the precise brain mechanisms that enable animals to overcome instinctive fears. Published in Science, the study in mice could have implications for developing therapeutics for fear-related disorders such as phobias, anxiety and post-traumatic stress disorder (PTSD).

The research team, led by Dr. Sara Mederos and Professor Sonja Hofer, mapped out how the brain learns to suppress responses to perceived threats that prove harmless over time.

“Humans are born with instinctive fear reactions, such as responses to loud noises or fast-approaching objects,” explains Dr. Mederos, Research Fellow in the Hofer Lab at SWC.