Summary: New research reveals how the body’s circadian clock regulates macrophage activity, influencing immune system inflammation throughout the day. Activation of the NLRP3 inflammasome, a key component in the immune response, peaks during the morning when macrophages are most efficient. This daily rhythm is driven by mitochondrial activity, explaining why inflammatory conditions like arthritis often worsen in the morning.
The findings open doors to time-targeted therapies, potentially improving treatments for diseases driven by overactive inflammasomes. Understanding the immune system’s internal clock could lead to precise interventions for inflammatory disorders.
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