Yale researchers have made an unexpected discovery—turncoat T cells that help a tumor evade other cancer-fighting immune T cells—in a study of patients living with advanced melanoma.
The study by Yale Cancer Center (YCC) researchers at Yale School of Medicine (YSM) discovered that not all CD8+ T cells are allies in a body’s fight against cancer cells. Patients living with severe melanoma who had increased levels of suppressor, regulatory CD8+ T cells had worse survival outcomes.
The study is published in the journal Nature Immunology.
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