Summary: Researchers have identified a protein complex, TrkC-PTPσ, that plays a key role in the structural organization of synapses in the brain, impacting cognitive behaviors. By studying this complex, scientists uncovered how it regulates synaptic protein phosphorylation, essential for healthy brain function. Disruptions in this protein complex led to anxiety-like behaviors in mice, providing insights into mental health conditions like anxiety and autism.
The study sheds light on synaptic mechanisms that could help develop new therapeutic strategies. These findings advance our understanding of synapse function and its role in cognitive disorders, bringing hope for targeted treatment options in the future.
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