#eyehealth #aging #antiaging #cellularpathology #MacularDegeneration #AgeRelatedMacularDegeneration #retina #eyehealth #lysosomedysfunction #drusendeposits #stemcells #research
A team of researchers reveals the cellular pathology of “dry” age-related macular degeneration (AMD); discovering the potential source of dysfunction in the process whereby cells in the retina remove waste.
What
The team from NIH and Johns Hopkins University, Baltimore, reported the details of how alterations in a factor called AKT2 affect the function of lysosome organelles, and results in the production of drusen deposits in the retina, which is a hallmark sign of dry age-related macular degeneration. The researchers suggest that the findings of drusen formation are a downstream effect of AKT2-related lysosome dysfunction and could point to a new target for therapeutic intervention.
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