An unusual protein structure known as a “rippled beta sheet,” first predicted in 1953, has now been created in the laboratory and characterized in detail using X-ray crystallography.
The new findings, published in July in Chemical Science, may enable the rational design of unique materials based on the rippled sheet architecture.
“Our study establishes the rippled beta sheet layer configuration as a motif with general features and opens the road to structure-based design of unique molecular architectures, with potential for materials development and biomedical applications,” said Jevgenij Raskatov, associate professor of chemistry and biochemistry at UC Santa Cruz and corresponding author of the paper.
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