Brain cells with the same “birthdate” are more likely to wire together into cooperative signaling circuits that carry out many functions, including the storage of memories, a new study finds.
Led by researchers from NYU Grossman School of Medicine, the new study on the brains of mice developing in the womb found that brain cells (neurons) with the same birthdate showed distinct connectivity and activity throughout the animals’ adult lives, whether they were asleep or awake.
Published online August 22 in Nature Neuroscience, the findings suggest that evolution took advantage of the orderly birth of neurons—by gestational day—to form localized microcircuits in the hippocampus, the brain region that forms memories. Rather than attempting to create each new memory from scratch, the researchers suggest, the brain may exploit the stepwise formation of neuronal layers to establish neural templates, like “Lego pieces,” that match each new experience to an existing template as it is remembered.
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