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Carboxyl-terminus of Hsp70-Interacting Protein (CHIP) is an E3 ubiquitin ligase that marks misfolded substrates for degradation. Hyper-activation of CHIP has been implicated in multiple diseases, including cystic fibrosis and cancer, suggesting that it may be a potential drug target. However, there are few tools available for exploring this possibility. Moreover, the best ways of inhibiting CHIP’s function are not obvious, as this complex protein is composed of a tetratricopeptide repeat (TPR) domain, a U-box domain, and a coiled-coil domain that mediates homodimerization.

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What can a moon’s tidal friction teach us about its formation and evolution? This is what a recent study published in Science Advances hopes to address as a team of researchers at the University of California Santa Cruz investigated a connection between the spin rate and tidal energy on Saturn’s moon, Titan, to determine more about Titan’s interior. This study has the potential to help researchers better understand the internal processes of Titan, leading to better constraints on the existence of a subsurface ocean.

For the study, the researchers used a combination of data obtained by NASA’s now-retired Cassini spacecraft and a series of mathematical calculations to determine Titan’s tidal dissipation, which is the amount of tidal energy lost in an object from friction and other processes, and for which the only moons in the solar system this has been successfully been accomplished being the Earth’s Moon and Jupiter’s volcanic moon, Io. Better understanding a moon’s tidal dissipation helps researchers better understand its formation and evolution, which the researchers successfully estimated for Titan.

“Tidal dissipation in satellites affects their orbital and rotational evolution and their ability to maintain subsurface oceans,” said Dr. Brynna Downey, who is a postdoctoral researcher at the Southwest Research Institute in Colorado and lead author of the study. “Now that we have an estimate for the strength of tides on Titan, what does it tell us about how quickly the orbit is changing? What we discovered is that it’s changing very quickly on a geologic timescale.”

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Crossing the blood–brain barrier in primates is a major obstacle to gene delivery in the brain. Here an adeno-associated virus variant (AAV.CAP-Mac) is identified and demonstrated for crossing the blood–brain barrier and delivering gene sequences to the brain of different non-human primates species.

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For the first time, researchers have been able to measure the quantum state of electrons ejected from atoms that have absorbed high-energy light pulses. This is thanks to a new measurement technique developed by researchers at Lund University in Sweden. The results can provide a better understanding of the interaction between light and matter.

When high-energy light with a very short frequency in the extreme ultraviolet or X-ray range interacts with atoms or molecules, it can cause an electron to be “detached” from the atom and ejected in a process called the . By measuring the emitted electron and its kinetic energy, a lot of information can be obtained about the atom being irradiated. This is the basic principle of photoelectron spectroscopy.

The electron that is emitted, known as the photoelectron, is often treated as a classical particle. In reality, the photoelectron is a quantum object that must be described quantum mechanically, as it is so small that at that scale the world is described in terms of quantum mechanics. This means that special rules applied in quantum mechanics have to be used to describe the photoelectron, because it is not just an ordinary small particle but also behaves like a wave.

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A study in mice by Northwestern Medicine researchers has now identified a critical difference in how immune system macrophages help repair the heart in newborns versus adults after a heart attack. They found that in newborns, macrophages perform a process called efferocytosis, which recognizes and eats dying cells. This process triggers the production of a bioactive lipid called thromboxane, signaling nearby heart muscle cells to divide, and allowing the heart to regenerate damaged heart muscle. In contrast, efferocytosis by adult macrophages ultimately culminates in fibrotic scarring.

The study highlights a fundamental difference in how the immune system drives healing based on age and could point to strategies for improving tissue repair after heart attack in adults.

“Understanding why newborns can regenerate their hearts while adults cannot will open the door to developing treatments that could ‘reprogram’ adult macrophages,” said first and co-corresponding author Connor Lantz, PhD, lead scientist of the bioinformatics core at the Comprehensive Transplant Center at Northwestern University Feinberg School of Medicine.

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Rigid, lizard-like tails are simple, but mammal-style tails may be lighter and better for space. Researchers studied how tails aid midair maneuverability in animals and robots, focusing on inertial appendages that generate body rotation.

Inspired by lizards and geckos, roboticists have designed rigid, single-plane tails to enhance stability and control in aerial and terrestrial robots. Some robotic tails aid in landing, flight reorientation, and high-speed turns. However, vertebrate (like cats and squirrels) tails are more complex, consisting of multiple vertebrae that allow for diverse movements.

By analyzing mammalian tails, researchers found that increasing bone segments within the same length enhances rotational ability. To evaluate tail effectiveness, they developed simulations optimizing tail trajectories for precise body rotations. Unlike previous models that assumed rigid structures, their approach considers deformability and realistic control constraints.

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