Researchers led by Jean-Paul Noel at the University of Minnesota, United States, have decoupled intentions, actions and their effects by manipulating the brain-machine interface that allows a person with otherwise paralyzed arms and legs to squeeze a ball when they want to.
Published in the open-access journal PLOS Biology, the study reveals temporal binding between intentions and actions, which makes actions seem to happen faster when they are intentional.
Separating intentions from actions was made possible because of a brain-machine interface. The participant was paralyzed with damage to their C4/C5 vertebrae and had 96 electrodes implanted in the hand region of their motor cortex.
Researchers at the University of Oklahoma have made a discovery that could potentially revolutionize treatments for antibiotic-resistant infections, cancer and other challenging gram-negative pathogens without relying on precious metals.
Currently, precious metals like platinum and rhodium are used to create synthetic carbohydrates, which are vital components of many approved antibiotics used to combat gram-negative pathogens, including Pseudomonas aeruginosa, a notorious hospital-acquired infection responsible for the deaths of immunocompromised patients. However, these elements require harsh reaction conditions, are expensive to use and are harmful to the environment when mined.
In an innovative study published in the journal Nature Communications, an OU team led by Professor Indrajeet Sharma has replaced these precious metals with either blue light or iron, achieving similar results with significantly lower toxicity, reduced costs, and greater appeal for researchers and drug manufacturers.
During viral infection, the innate immune system utilizes a variety of specific intracellular sensors to detect virus-derived nucleic acids and activate a series of cellular signaling cascades that produce type I IFNs and proinflammatory cytokines and chemokines. Kaposi’s sarcoma-associated herpesvirus (KSHV) is an oncogenic double-stranded DNA virus that has been associated with a variety of human malignancies, including Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman disease. Infection with KSHV activates various DNA sensors, including cGAS, STING, IFI16, and DExD/H-box helicases. Activation of these DNA sensors induces the innate immune response to antagonize the virus. To counteract this, KSHV has developed countless strategies to evade or inhibit DNA sensing and facilitate its own infection. This review summarizes the major DNA-triggered sensing signaling pathways and details the current knowledge of DNA-sensing mechanisms involved in KSHV infection, as well as how KSHV evades antiviral signaling pathways to successfully establish latent infection and undergo lytic reactivation.
A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes.
The result was published in Cell Death & Differentiation. The team was led by Professor Zhao Guoping at the Hefei Institutes of Physical Science of the Chinese Academy of Sciences.
The efficacy of radiotherapy is largely limited by the DNA damage repair capacity of tumor cells. When ionizing radiation induces DNA double-strand breaks—the primary lethal damage—tumor cells often exhibit abnormal overexpression of DNA repair proteins, establishing a robust damage response system that drives clinical radioresistance. To address this challenge, the team deciphered the regulatory network of epigenetic modifications in DNA damage repair.
But classic risk factors do not seem to fully explain the recent rise in early-onset cancers, says Dr. Cathy Eng, director of the Young Adult Cancers Program at Vanderbilt University’s Ingram Cancer Center in Tennessee. Some of the trends are baffling; young, nonsmoking women, for example, are being diagnosed with lung cancer in strangely high numbers. Many times, Eng’s patients were extremely healthy: vegetarians, marathon runners, avid swimmers. “That’s why I really believe there’s other risk factors to account for this,” she says.
There’s no shortage of theories about what those may be. Many scientists point to modern diets, which tend to be heavy on potentially carcinogenic products—including ultra-processed foods, red meat, and alcohol—and may also contribute to weight gain, another cancer risk factor. The foods we eat can also affect the gut microbiome, the colony of microbes that lives in the digestive system and appears linked to overall health. Alterations to the gut microbiome via diet, or perhaps exposure to drugs like antibiotics, have also been implicated.
Other researchers blame the microplastics littering our environment and leaching into our food and water supplies, some of which, according to a 2024 study, have even shown up in cancer patients’ tumors. Other environmental factors could also be to blame, given that everything from cosmetics to food packaging contains substances that many researchers aren’t convinced are safe. Even our near constant exposure to artificial light could be messing with normal biological rhythms in ways that have profound health consequences, some research suggests.
Will a child who’s evaluated for autism later develop an intellectual disability? Can this be accurately predicted? Early-childhood experts in Quebec say they’ve have come up with a better way to find out.
In a study of 5,633 children drawn from three North American cohorts, clinician-researchers affiliated with Université de Montréal developed a new predictive model that combines a wide range of genetic variants with data on each stage of a young child’s development.
Their goal? To obtain reliable information as early as possible to predict the children’s developmental trajectory and thus offer more proactive support to those who may need it—namely, parents trying to better understand and anticipate their child’s needs.
One of the challenges of fighting pancreatic cancer is finding ways to penetrate the organ’s dense tissue to define the margins between malignant and normal tissue. A new study uses DNA origami structures to selectively deliver fluorescent imaging agents to pancreatic cancer cells without affecting normal cells.
The study, led by University of Illinois Urbana-Champaign mechanical science and engineering professor Bumsoo Han and professor Jong Hyun Choi at Purdue University, found that specially engineered DNA origami structures carrying imaging dye packets can specifically target human KRAS mutant cancer cells, which are present in 95% of pancreatic cancer cases.
“This research highlights not only the potential for more accurate cancer imaging, but also selective chemotherapy delivery, a significant advancement over current pancreatic ductal adenocarcinoma treatments,” said Han, who is also affiliated with the Cancer Center at Illinois. “The current process of cancerous tissue removal through surgical resection can be improved greatly by more accurate imaging of tumor margins.”
Have you ever considered that everything you know—the planets, stars, galaxies, and even you—might actually exist inside an enormous black hole? What if the universe we call home is merely the interior of a cosmic leviathan, swallowing light from another reality we can never directly observe?
For decades, black holes have captured our imagination as cosmic monsters devouring everything in their path, where even light cannot escape their gravitational clutches. But recent discoveries are forcing scientists to consider an extraordinary possibility: that our entire universe might itself be a black hole. This isn’t science fiction—it’s a serious scientific hypothesis with growing evidence behind it.
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Astronomers analyzing Webb’s data have found that early galaxies seem to favor a particular spin direction—an observation that defies the Cosmological Principle. If confirmed, this could suggest that the universe was born with a fundamental rotation, pointing toward radical theories like black hole cosmology.
But this is just the beginning. The telescope has also spotted galaxies forming far earlier than they should have, some potentially dating back to just 168 million years after the Big Bang. These findings contradict existing models of cosmic evolution, raising the possibility that our understanding of time, expansion, and even reality itself may be flawed.
Adding to the mystery, supermassive black holes have been detected in the early universe, defying expectations of how they should form. Could they be remnants of a previous cosmic cycle? Some researchers are now revisiting the Cyclical Universe Theory, which suggests our universe may be part of an infinite loop of creation and destruction.
With every new revelation, JWST is not just answering questions—it’s creating new ones. Are we on the verge of a fundamental shift in physics, or is there a simpler explanation we have yet to uncover?
The James Webb Space Telescope has uncovered some of the most perplexing discoveries in modern astronomy, challenging everything we thought we knew about the cosmos. From galaxies that appear too massive and too developed for their age to a potential imbalance in galactic rotation, these findings are shaking the foundations of the Big Bang model. Could our universe itself have been born inside a black hole?
