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Lipid Nanoparticle Protein Coronas Arise through Lipoprotein Fusion Rather Than Shelllike Adsorption

An insightful paper providing evidence that lipoproteins incorporate themselves into lipid nanoparticles (LNPs) rather than just adhering the surface as people previously thought. This may inform the design of better LNP delivery systems in the future.

Abstract. The protein corona influences the in vivo biodistribution of ionizable lipid nanoparticles (LNPs) in nucleic acid delivery, yet their structural architecture remains poorly defined. Using cryo-transmission electron microscopy, we visualized LNP–protein interactions in their native state. We show that, unlike the discrete “fuzzy” shells observed on hard nanoparticles, LNPs displayed no peripheral protein shell. Instead, controlled incubation and competitive “dual-particle” assays, supported by molecular dynamics simulations, indicate that LNP membranes undergo localized thickening and electron-dense remodeling consistent with lipoprotein integration rather than surface adsorption. Similar features were observed in extracellular vesicles, suggesting that this behavior is shared among lipid-based carriers, and proteomic analysis identified apolipoproteins as the dominant associated proteins. Together, these findings support a model in which the biological identity of LNPs arises through membrane remodeling rather than shell-like adsorption and provide a framework for the rational design of targeted nanomedicines.

Tim Cook Steps Down: The Man Who Made Apple a $3 TRILLION Empire

Tim Cook is stepping down after 11 consequential years as CEO of Apple, one of the most innovative companies in the world. Following founder and visionary creator Steve Jobs, Cook was the right person for the job as Apple organized and consolidated Jobs’s brilliant insights in product development, then scaled them — and the company — across the globe.

Born in a small town in Alabama, Cook attended Auburn University and Duke University. He worked at IBM before being recruited by Jobs to join Apple in Silicon Valley, where he put his operational talents to work. As CEO, under Cook’s leadership, Apple became the most valuable publicly traded company in the world, growing into a multi-trillion-dollar enterprise while expanding its services revenue stream. Under his leadership, functionality was enhanced across Apple products, the integrity of its ecosystem was maintained, and multiple manufacturing bases were added to its supply chain. Along the way, Apple became an economic powerhouse.

Tim Cook will continue to impact the company as executive chairman. John Ternus will become the new CEO.

PAI-1 Impacts Telomere Length, Cell Senescence, And Longevity

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Hundreds feared stuck in hydropower tunnels as flood deaths surpass 950 in Nepal and China

KATHMANDU, Nepal (AP) — Rescuers raced Monday to free hundreds of workers believed to be trapped in tunnels at hydropower sites that were buried in mud by catastrophic flooding on the Nepal-China border, as the death toll climbed and increasingly desperate families searched for missing loved ones.

The combined deaths in Nepal and China surpassed 950, with more than 4,400 people missing. A private-sector association representing power companies said at least 900 workers were unaccounted for at 12 hydropower projects damaged by the flash floods in Nepal’s Rasuwa and Nuwakot districts.

About 500 of those workers were believed to be trapped in tunnels. At least one expert said that some workers could have access to oxygen, but others warned that the chances of finding survivors were diminishing. As the rescue efforts intensified, four bodies were recovered from three mud-filled tunnels, Nepal’s army said.

New guidelines recommend all patients with heart disease are tested for kidney disease

The first-ever European Society of Cardiology Guidelines on the management of cardiovascular disease and chronic kidney disease have been developed in collaboration with the European Renal Association. The new guidelines were published online in the European Heart Journal and presented at ESC Congress 2026 on Aug. 29.

Chronic kidney disease (CKD) is defined as the presence of abnormalities of kidney structure or function for at least three months, with implications for health. It is estimated that around 100 million people in Europe have CKD, all of whom are at increased risk of a wide range of cardiovascular diseases (CVD) as a result of their kidney disease.

“The disability and lifetime lost to each disease are profound, but CKD can accelerate CVD and vice versa, resulting in cardiovascular events and the need for dialysis much earlier in life,” said Task Force Chair Associate Professor Kevin Damman from University Medical Center Groningen, Netherlands.

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