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How common is Alzheimer’s? Blood-test study holds surprises

A Nature analysis of a major Norwegian study challenges existing estimates of Alzheimer’s prevalence, finding that 25% of people aged 85–89 have dementia with Alzheimer’s pathology — far higher than previous 7–13% estimates — while preclinical Alzheimer’s in younger seniors (70−74) occurs at only 8% versus earlier 22% estimates. Using blood biomarker pTau217 in 11,486 participants, researchers identified that 10% of over-70s had dementia, 10% had mild cognitive impairment, and 10% had preclinical Alzheimer’s, but warn that blood tests alone are insufficient for widespread screening due to potential harm from false positives. The discrepancies highlight how previous studies may have been skewed by selection bias, while demonstrating that blood-based biomarkers require careful interpretation and comprehensive clinical assessment.


A survey of Alzheimer’s disease prevalence in Norway confirms earlier estimates and might show how education level relates to risk.

Physical and Cognitive Activities and Trajectories of AD Neuroimaging BiomarkersLongitudinal Analysis in the Mayo Clinic Study of Aging

Background and ObjectivesEngagement in physical and cognitive activities is associated with a decreased risk of mild cognitive impairment (MCI) and dementia, but the association with Alzheimer disease (AD) neuroimaging biomarkers is less clear. We thus…

Scientists Learn To Steer Light at the Nanoscale, Setting New Records

Researchers have introduced an innovative two-step excitation approach that makes it possible to efficiently generate and clearly separate different modes of hyperbolic polaritons. An international collaboration of scientists has introduced a new approach for generating and manipulating extremely

NASA’s Webb, Curiosity Named in TIME’s Best Inventions Hall of Fame

Two icons of discovery, NASA’s James Webb Space Telescope and NASA’s Curiosity rover, have earned places in TIME’s “Best Inventions Hall of Fame,” which recognizes the 25 groundbreaking inventions of the past quarter century that have had the most global impact, since TIME began its annual Best Inventions list in 2000. The inventions are celebrated in TIME’s December print issue.

“NASA does the impossible every day, and it starts with the visionary science that propels humanity farther than ever before,” said Nicky Fox, associate administrator, Science Mission Directorate, NASA Headquarters in Washington. “Congratulations to the teams who made the world’s great engineering feats, the James Webb Space Telescope and the Mars Curiosity Rover, a reality. Through their work, distant galaxies feel closer, and the red sands of Mars are more familiar, as they expanded and redefined the bounds of human achievement in the cosmos for the benefit of all.”

Decades in the making and operating a million miles from Earth, Webb is the most powerful space telescope ever built, giving humanity breathtaking views of newborn stars, distant galaxies, and even planets orbiting other stars. The new technologies developed to enable Webb’s science goals – from optics to detectors to thermal control systems – now also touch Americans’ everyday lives, improving manufacturing for everything from high-end cameras and contact lenses to advanced semiconductors and inspections of aircraft engine components.

On biological and artificial consciousness: A case for biological computationalism

The rapid advances in the capabilities of Large Language Models (LLMs) have galvanised public and scientific debates over whether artificial systems might one day be conscious. Prevailing optimism is often grounded in computational functionalism: the assumption that consciousness is determined solely by the right pattern of information processing, independent of the physical substrate. Opposing this, biological naturalism insists that conscious experience is fundamentally dependent on the concrete physical processes of living systems. Despite the centrality of these positions to the artificial consciousness debate, there is currently no coherent framework that explains how biological computation differs from digital computation, and why this difference might matter for consciousness.

BREAKING: Tesla Robotaxi DROPS Safety Monitors!

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Inside SpaceX’s Pre-IPO Share Buyback and Who Gets Access

SpaceX is preparing for a potential IPO by buying back shares from institutional holders and allowing existing shareholders to sell shares, while its affiliate company Tesla is making progress in autonomous driving technology with plans to launch robo-taxis in multiple cities ## Questions to inspire discussion.

SpaceX Investment Access.

🔐 Q: How can individual investors access SpaceX shares before the IPO?

A: Investors must be accredited with liquid net worth over $1M (excluding home) and can access shares through special purpose vehicles (SPVs) that charge upfront fees and 10% carry on returns.

💰 Q: What is the minimum investment required to buy SpaceX shares directly?

A: Direct SpaceX share purchases require $50M-$1B investments due to SEC’s 2,000 shareholder cap for private companies, making SPVs the only option for smaller investors.

Efficient site-specific integration of kilobase-length DNA fragments in plant cells via Kp03 recombinase

Employing this sensitive assay, we revealed that the integration efficiencies of the 9.9-kb attP-containing DNA donor in rice cells remained remarkably high at 80.5%, relative to the 3.4-kb attP-containing donor, which was set as the baseline for 100% integration efficiency (Figure 2 B). However, a significant decrease in recombination efficiency was observed for donor DNA exceeding 17 kb. The integration efficiency of the 17.4-kb attP-containing plasmid decreased to 42.5% (Figure 2 B), and for the 27.3-kb attP-containing plasmid, it further declined to 8.2% (Figure 2 B). Similar trends were observed in Arabidopsis, with recombination efficiencies of 51.4%, 26.5%, and 9.0% for the 9.9-, 17.4-, and 27.3-kb attP-containing donors, respectively (Figure 2 C). Furthermore, PCR amplification of the attL junctions confirmed that the donor attP sequences had indeed been recombined into the attB as expected (Figures 2 D and 2E). Collectively, these results demonstrate that the Kp03 system can efficiently mediate targeted insertion of large DNA donors up to 27.3 kb in plant cells.

Interestingly, in addition to donor size, we also observed that Kp03-mediated recombination efficiency is sensitive to temperature, exhibiting differential efficiency under varying thermal conditions (Figure S2).

Cardiovascular Disease Biomarker Deep Dive (Test #7 In 2025)

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