Vitamin D is not only an essential nutrient, but also the precursor of the hormone calcitriol, indispensable for health. It regulates the uptake of phosphate and calcium necessary for bones by the intestines, as well as cell growth and the proper function of muscles, nerve cells, and the immune system.
Now, researchers have shown for the first time in Frontiers in Endocrinology that a particular gene called SDR42E1 is crucial for taking up vitamin D from the gut and further metabolizing it—a discovery with many possible applications in precision medicine, including cancer therapy.
“Here we show that blocking or inhibiting SDR42E1 may selectively stop the growth of cancer cells,” said Dr. Georges Nemer, a professor and associate dean for research at the University College of Health and Life Sciences at Hamad Bin Khalifa University in Qatar, and the study’s corresponding author.