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Is the universe infinite, Aristotle asked in 350 BCE, “or is this an impossibility? The decision … is … all-important to our search for the truth.” The Greek philosopher opined that “the heavens” (meaning the moon, planets, sun and other stars) travel around the Earth in circles, and that a “body which moves in a circle is not endless or infinite, but has its limit.” Moreover, he assumed that Earth sits at the center of the universe. In that case, the universe must be finite, Aristotle reasoned, for otherwise it could not have a center. With that, he’d apparently resolved an issue that had confounded both his predecessors and his contemporaries.

Circular as Aristotle’s logic was, his conclusion could still be correct. More than two millennia later, we still can’t be sure if the universe is finite or infinite. The universe could be boundless, continuing in all directions without end, or it could be sealed up in a compact shape such as a sphere or doughnut.

Of course, modern scientists have wondered about this issue as well. They’ve devised strategies to investigate the universe’s overall topology, using methods more rigorous than Aristotle’s. The first tests, conducted about two decades ago, linked a range of possible topologies to signals that might have been spotted in astronomical data. Efforts to find those signals have come up short, but hope may be on the horizon.

s future, predicting a $10 trillion valuation driven by the launch of the Optimus robot and full self-driving technology, alongside ambitious plans for a Robo taxi service and significant production growth +# ## Key Insights.

S vertically integrated supply chains and in-house development of Optimus components make it difficult for competitors to replicate their success in robotics and AI. + Economic Impact.

S most valuable company, worth more than the next 5 largest companies combined, primarily due to autonomous vehicles and robots. + ⏰Autonomous Tesla vehicles are expected to increase car utility by 5x, operating 55 hours/week instead of the typical 10 hours, enabling 24/7 ride-hailing and delivery services.

Safety and Technology.

Neoadjuvant therapy with hedgehog inhibitors has an overall response rate (ORR) of 71%, but adverse events (AEs) like fatigue, muscle cramps, dysgeusia, and hair loss often lead to discontinuation and low compliance.

OVs represent a class of intratumoral therapeutics that might be a safe and effective neoadjuvant therapy for difficult-to-resect BCCs.

Talimogene laherparepvec (T-VEC) is an OV, a genetically engineered herpes simplex virus 1 (HSV1), approved for treating injectable, unresectable melanoma lesions in the United States and Europe. T-VEC has a dual mode of action and can alter the tumor microenvironment (TME) by activating adaptive and innate immunity.

BIG Projects To Solve Pressing Issues In Science — Dr. Christopher Stubbs, Ph.D. — Professor of Physics and Astronomy, Harvard University.


Dr. Christopher Stubbs, Ph.D. is the Samuel C. Moncher Professor of Physics and Astronomy, and has recently served as the Dean of Science in the Faculty of Arts and Sciences, at Harvard University (https://astronomy.fas.harvard.edu/peo

Dr. Stubbs is an experimental physicist working at the interface between particle physics, cosmology and gravitation. His interests include experimental tests of the foundations of gravitational physics, searches for dark matter, characterizing the dark energy, and observational cosmology.

On Thursday January 30th, astronauts Suni Williams and Butch Wilmore are doing a 6.5-hour spacewalk outside the International Space Station. Among other goals, they’ll be collecting surface samples from the station to analyze for the presence of microbes.

The ISS “surface swab” is part of the ISS External Microorganisms project. It was developed to understand how microorganisms are transported by crew members to space. It also seeks to understand what happens to those “mini-critters” in the space environment.

NASA will provide live coverage of the walk which will also conduct some other maintenance on the station along with the sampling activities.

When astronomers detected the first long-predicted gravitational waves in 2015, it opened a whole new window into the Universe. Before that, astronomy depended on observations of light in all its wavelengths.

We also use light to communicate, mostly radio waves. Could we use gravitational waves to communicate?

The idea is intriguing, though beyond our capabilities right now. Still, there’s value in exploring the hypothetical, as the future has a way of arriving sooner than we sometimes think.

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Researchers have developed a new electrically active biomaterial that can be transplanted into the body to improve recovery following central nervous system injuries. The material acts as a scaffold that also provides electrical stimulation.