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Since most cells naturally repel DNA, delivering these nanodevices into cells requires specialized techniques, such as transfection methods and transformation protocols. Once inside, cellular factors such as salt concentration, molecular crowding, and heterogeneous environments influence strand displacement reactions. To overcome the limitations of direct delivery, researchers are also developing transcribable RNA nanodevices encoded into plasmids or chromosomes, allowing cells to express these circuits.

Toward Smart DNA Machines and Biocomputers

DNA strand displacement has been applied to the innovation of computational models. By integrating computational principles with DNA strand displacement, the structured algorithms of traditional computing can be combined with random biochemical processes and chemical reactions in biological systems, enabling biocompatible models of computation. In the future, DNA strand displacement may enable autonomously acting DNA nanomachines to precisely manipulate biological processes, leading to quantum leaps in healthcare and life science research.

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Astronomers tallying up all the normal matter—stars, galaxies and gas—in the universe today have come up embarrassingly short of the total matter produced in the Big Bang 13.6 billion years ago. In fact, more than half of normal matter—half of the 15% of the universe’s matter that is not dark matter—cannot be accounted for in the glowing stars and gas we see.

New measurements, however, seem to have found this missing matter in the form of very diffuse and invisible ionized hydrogen gas, which forms a halo around galaxies and is more puffed out and extensive than astronomers thought.

The findings not only relieve a conflict between astronomical observations and the best, proven model of the evolution of the universe since the Big Bang, they also suggest that the massive black holes at the centers of galaxies are more active than previously thought, fountaining gas much farther from the than expected—about five times farther, the team found.

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According to new research, the earliest seeds of structures may have been laid down by gravitational waves sloshing around in the infant universe.

Cosmologists strongly suspect that the extremely underwent a period of exceptionally rapid expansion. Known as , this event expanded the universe by a factor of at least 1060 in less than a second. Powering this event was a new ingredient in the cosmos known as the inflaton, a strange quantum field that ramped up, drove inflation, and then faded away.

Inflation didn’t just make the universe big. It also laid down the seeds of the first structures. It did so by taking the quantum foam, the subatomic fluctuations in spacetime itself, and expanding that along with everything else. Slowly, over time, those fluctuations grew, and hundreds of millions of years later they became the and galaxies, ultimately leading to the largest structure in the universe, the cosmic web.

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