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Michaela Leung: “Oxygen is currently difficult or impossible to detect on an Earth-like planet. However, methyl halides on Hycean worlds offer a unique opportunity for detection with existing technology.”


What can methyl halides, which are gases that consist of one carbon and three hydrogen atoms while being attached to a halogen atom, help scientists identify life beyond Earth? This is what a recent study published in The Astrophysical Journal Letters hopes to address as an international team of researchers investigated how methyl halides on exoplanets known as “Hycean” worlds could indicate the presence of life as we know it, or even as we don’t know it. Hycean exoplanets possess liquid water oceans with a hydrogen atmosphere above them, potentially enabling appropriate surface temperatures and pressures for life to exist.

For the study, the researchers discussed the potential for using NASA’s James Webb Space Telescope (JWST) to observe large exoplanets orbiting red dwarf stars, which are smaller and cooler than our Sun. The researchers noted that recent observations of K2-18 b and TOI-270 d, which are designated as Super-Earth and Neptune-like exoplanets, respectively, while each orbiting red dwarf stars. Additionally, such exoplanets could be ideal targets for JWST to identify methyl halides in their atmospheres. The reason Hycean exoplanets are considered ideal targets is due to the difficulty of observing Earth-sized exoplanets orbiting brighter stars.

An excellent concise newsletter article by the legendary Ben Reinhardt on how to think about scaling new technologies, what kinds of bottlenecks can occur, and strategies for maximizing chances of success. #development #industry #biotech #tech


A particular failure mode that we’ve noticed among scientists and engineers doing ambitious technology research is ignoring the question “does this technology scale?” It’s a question that gets thrown around a lot by VCs and technology analysts, but people rarely unpack what that means and (I suspect) many of us don’t even know.

SAN JOSE, Calif., March 18, 2025 (GLOBE NEWSWIRE) — GTC — NVIDIA today unveiled NVIDIA Spectrum-X™ and NVIDIA Quantum-X silicon photonics networking switches, which enable AI factories to connect millions of GPUs across sites while drastically reducing energy consumption and operational costs. NVIDIA has achieved the fusion of electronic circuits and optical communications at massive scale.

As AI factories grow to unprecedented sizes, networks must evolve to keep pace. NVIDIA photonics switches are the world’s most advanced networking solution. They integrate optics innovations with 4x fewer lasers to deliver 3.5x more power efficiency, 63x greater signal integrity, 10x better network resiliency at scale and 1.3x faster deployment compared with traditional methods.

1. Introduction.

The natural production of EGF, a short polypeptide hormone, promotes the processes of proliferation, expansion, and division of cells [1]. For in vitro cell culture, EGF functions as a growth factor [2] and has an effective mitogenic effect on endothelial cells, fibroblasts, and most epithelial tissues. Its biological functions rely on associating itself with a specific cell membrane receptor [3]. Because EGF plays a crucial role as a mitogen in the proliferation of various cell types both in vivo and in vitro, it has been used in the therapeutic and cosmetic areas [4] to cover scars and reduce the appearance of aging skin [1]. Moreover, recombinant EGF is used topically for diabetic foot ulcers [5]. The structures and properties of proteins vary; favorable conditions are necessary for conformation, stability, and proper function. In contrast, a protein degrades, denatures, or precipitates when it is exposed to unfavorable conditions or when its natural environment changes suddenly. Recombinant human EGF is most frequently degraded by oxidation and deamidation [6]. These reactions typically have long-term implications. For protein solutions to remain stable and have a longer shelf life, excipients may need to be added, depending on how the protein is used in the experiment and other factors. When it comes to the chemical and physical degradation of proteins, the solution environment plays a crucial role in protein formulations. Of particular concern are buffer types, pH, and antioxidants [7]. Even though antioxidants assist in stability and solubility in liquid solutions, which help to preserve protein structure and function, they are frequently considered inactive ingredients in pharmaceutical compositions [8] [9].

Since an unstable protein solution can impact the product’s appearance, potency, purity, healing effects, and cell proliferation, in vitro protein stabilization is an essential practical consideration for the development of an effective EGF formulation. The stability of EGF in solution has been well documented in several in vivo solutions [10]. Though there have been numerous reports on EGF stability, none have specifically addressed treatment in cell culture conditions. Since it has a big influence on several aspects of the parenteral formulation creation process and EGF-based cell proliferation, the study of EGF stability in cell culture medium has gotten little attention. But since many of these in vitro tests are conducted in non-physiological settings, such as organic solvents or acidic solutions [11], they frequently fail to yield qualitatively positive results in cellular therapies.

Ma, W., Wang, W., Zhao, L. et al. Bone Res 13, 35 (2025). https://doi.org/10.1038/s41413-025-00416-1

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Cancer patients have an increased risk of venous thromboembolism (VTE), and VTE is the second most common cause of death among them. Anticoagulation plays a key role in the treatment of cancer-associated thrombosis (CAT). Low-molecular-weight heparin (LMWH) or direct oral anticoagulants (DOACs) are effective and generally safe options for cancer-associated VTE. However, those patients have a 10–20% risk of VTE recurrence in spite of using anticoagulants. The main reasons for recurrent VTE (rVTE) can be non-compliance, inadequate dosing of anticoagulants, thrombocytopenia and malignancy progression. Despite the publication of major guidelines regarding the management of CAT, the treatment of patients with rVTE is undefined. Treatment options for rVTE include bridging to LMWH in cases of oral anticoagulants use, LMWH dose escalation, and sometimes considering inserting a vena cava filter.

Patients with end-stage kidney disease initiating dialysis have a high incidence of pulmonary embolism (PE) and substantial mortality.


This cohort study examines the incidence and outcomes of pulmonary embolism as well as anticoagulant use among patients with end-stage kidney disease initiating dialysis.

“Our successful PDR is a testament to the expertise and dedication of our team,” Starlab CEO Tim Kopra said in the statement. “This milestone confirms that our space station design is technically sound and safe for astronaut crewed operations. Now, with our partners, we shift our focus to the full-scale development of the station, including the manufacturing of critical hardware and software integration.”

The 12,000-cubic-foot (340-cubic-meter) Starlab will be fitted with a robotic arm and a set of racks for microgravity experiments to enable companies and researchers to develop new products in space. Voyager also hopes to seal a contract with NASA to host the agency’s astronauts.

Is a 1953 independently made American black-and-white science fiction/comedy film, produced by A.D. Nast, Jr., Arch Oboler, and Sidney Pink, written and directed by Arch Oboler, and starring Hans Conried, Gloria Blondell, Billy Lynn, and Edwin Max. The film was distributed by United Artists.

Directed by Arch Oboler.
Screenplay by Arch Oboler.

Hans Conried as Kerry West.
Janet Warren as Carolyn West.
Billy Lynn as Coach Trout.
Edwin Max as the Television Deliveryman.
Gloria Blondell as the Bill Collector.
Evelyn Beresford as Old Lady Motorist.
Bob Jellison as the TV Shop Owner.
Norman Field as the Doctor.
Stephen Roberts as Head Treasury Agent.
Connie Marshall as Susie.
William Phipps as Student.
Lenore Kingston as Offended Phone Operator #2
Alice Backes as Offended Phone Operator #1
Brick Sullivan as Cop.

Words of the prophet.


What happens when AI surpasses human intelligence, accelerating its own evolution beyond our control? This is the Singularity, a moment where technology reshapes the world in ways we can’t yet imagine.
Futurist Ray Kurzweil predicts that by 2045, AI will reach this point, merging with human intelligence through Brain-Computer Interfaces (BCIs) and redefining the future of civilization. But as we move closer to this reality, we must ask: Will the Singularity be humanity’s greatest leap or its greatest risk?
Chapters.
00:00 — 00:48 Intro.
00:48 — 01:51 Technological Singularity.
01:51 — 05:09 Kurzweil’s Predictions and Accuracy.
05:09 — 07:32 The Path to the Singularity.
07:32 — 08:51 Brain-Computer Interfaces (BCIs)
08:51 — 12:14 The Singularity: What Happens Next?
12:14 — 14:14 The Concerns: Are We Ready?
14:14 — 15:11 The Countdown to 2045
The countdown has already begun. Are we prepared for what’s coming?
#RayKurzweil #Singularity #AI #FutureTech #ArtificialIntelligence #BrainComputerInterface