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Blood proteome regulation to control inflammation, age-associated organ dysfunction and mortality in sepsis

The amount of each of the more than a thousand different glycoproteins in your blood varies widely with the 10 most abundant glycoproteins accounting for 90 percent of the total mass. Finding a protein that isn’t in this top 10 is a bit like looking for Waldo if only one rendition of the character remained in a collection of every “Where’s Waldo” comic ever produced.

This range of disparity in protein concentration is termed dynamic range, and it makes it more difficult for scientists to identify less-abundant proteins and their matching receptors.

Scientists published findings in Nature Communications demonstrating a strategy for identifying less-abundant proteins that bind with a specific type of receptor termed an endocytic lectin, and namely the mannose receptor Mrc1 (also known as CD206 and MMR). This approach enabled the research team to uncover hundreds of binding partners that together predicted Mrc1’s roles in our health.

Lipid nanoparticle stereochemistry shapes mRNA delivery safety and efficacy, study reveals

A team from the Max-Planck-Institut für Kohlenforschung, Hokkaido University, and Osaka University has discovered that subtle differences in molecular structure can have a major impact on the performance of mRNA-based drugs. Their findings, published in the Journal of the American Chemical Society, open the door to the development of safer and more effective vaccines and therapies.

To deliver therapeutic nucleic acids like mRNA into cells, scientists rely on (LNPs)—tiny, fat-based carriers that protect fragile genetic material, enabling it to survive in the body and reach target cells. A key component of these LNPs are ionizable lipids, which help mRNA enter cells and then release it effectively. One such lipid, ALC-315, was notably used in the Pfizer/BioNTech COVID-19 vaccine, a medical breakthrough that played a critical role in controlling the global pandemic.

Experimental Demonstration of Attoseconds-at-Harmonics at the SASE3 Undulator of the European XFEL

We report on observations of single spike spectra (3–13% of events) upon employing a previously proposed method for single spike generation via harmonic conversion. The method was tested at the soft X-ray SASE3 undulator of the European XFEL. The first part of the undulator allows one to amplify bunching at the fundamental as well as the higher harmonics. The downstream undulator is tuned to a harmonic, the fourth in our case, to amplify pulses with a shorter duration. We estimate the generated pulse duration within such a subset of short pulses at a level of 650 as. Considering the demonstrated probability of single spike events, this method is attractive for high repetition-rate free electron lasers.

AI Co-Processors, NPUs and The Future of Cutting-Edge Artificial Intelligence

This week’s Fish Fry is all about AI inference, NPUs and the Tensilica NeuroEdge 130 AI Co-Processor! My guest is Amol Borkar from Cadence Design Systems and we are chatting about the latest trends in AI inferencing, why there is a greater need now for AI co-processors than ever before and the multitude of benefits that the Tensilica NeuroEdge 130 AI Co-Processor can bring to your next design.

Scientists give robots a sense of touch with fabric that mimics human skin

Robots excel at many things, but having a good sense of touch is not among them. Whether dropping items or pinching them too tightly, which crushes the object, many robots struggle with these basic skills that humans have mastered.

Over the years, scientists have equipped robots with cameras and other tools that enable the machines to better sense objects. But a simple and cost-effective solution remains elusive.

A new electronic textile (E-textile), under development at the University at Buffalo, aims to address this problem. The technology, described in a study published July 30 in Nature Communications, mimics how nerves in our hands sense pressure and slipping while grasping objects.

Flexible optoelectronic device with minimal defects fabricated at just 90°C

Dr. Jung-Dae Kwon’s research team at the Energy & Environmental Materials Research Division of the Korea Institute of Materials Science (KIMS) has successfully developed an amorphous silicon optoelectronic device with minimal defects, even using a low-temperature process at 90°C. The findings are published in the journal Advanced Science.

Notably, the team overcame the limitations of high-temperature processing by precisely controlling the hydrogen dilution ratio—the ratio of hydrogen to silane (SiH4) gas—enabling the fabrication of high-performance flexible optoelectronic devices (sensors that detect light and convert it into ).

Flexible optoelectronic devices are key components of next-generation , such as wearable electronics and image sensors, and require the precise deposition of thin films on thin, bendable substrates. However, a major limitation has been the necessity of high-temperature processing above 250°C, making it difficult to apply these devices to heat-sensitive flexible substrates.

Earth’s Gravity Might Be Warping Quantum Mechanics, Say Physicists

Scientists propose a groundbreaking experiment using quantum computers and atomic clocks to test whether gravity alters the fundamental rules of quantum theory. A recent study featured in the journal PRX Quantum reveals how a network of quantum computers equipped with optical clocks can be used t

Alzheimer’s Gene Therapy Shows Promise in Preserving Cognitive Function

Someone posted this, and reminded me I didn’t Researchers at University of California San Diego School of Medicine have developed a gene therapy for Alzheimer’s disease that could help protect the brain from damage and preserve cognitive function. Unlike existing treatments for Alzheimer’s that target unhealthy protein deposits in the brain, the new approach could help address the root cause of Alzheimer’s disease by influencing the behavior of brain cells themselves.

Alzheimer’s disease affects millions of people around the world and occurs when abnormal proteins build up in the brain, leading to the death of brain cells and declines in cognitive function and memory. While current treatments can manage symptoms of Alzheimer’s, the new gene therapy aims to halt or even reverse disease progression.

Studying mice, the researchers found that delivering the treatment at the symptomatic stage of the disease preserved hippocampal-dependent memory, a critical aspect of cognitive function that is often impaired in Alzheimer’s patients. Compared to healthy mice of the same age, the treated mice also had a similar pattern of gene expression, suggesting that the treatment has the potential to alter the behavior of diseased cells to restore them to a healthier state.

By reprogramming brain cells, a new gene therapy approach for Alzheimer’s developed by UC San Diego researchers could address the root cause of the disease to halt its progression.

TISSIUM Announces Clinical Results of COAPTIUM® CONNECT System for Atraumatic Sutureless Nerve Repair

Paris, France, Cambridge, USA, April 2nd, 2025 – TISSIUM, a privately-owned medtech company developing biomorphic programmable polymers for tissue reconstruction, is proud to unveil clinical data which were presented at the IFSSH Congress in Washington, D.C. on March 27, 2025, demonstrating the potential of its COAPTIUM® CONNECT System, an innovative atraumatic sutureless solution for peripheral nerve repair.

Peripheral nerve injuries pose a significant burden, often resulting in impaired nerve function, reduced dexterity, and decreased quality of life. Traditional microsurgical repair with sutures, while effective, presents challenges such as inconsistent functional recovery and the potential for additional nerve trauma. The need for disruptive technologies in nerve repair is clear—TISSIUM’s COAPTIUM® CONNECT System offers an innovative atraumatic sutureless method for coaptation of severed nerves.

Study Overview & Key Findings

A prospective, single-arm study was conducted in patients with digital nerve injuries to assess the COAPTIUM® CONNECT System. The trial enrolled 12 patients, of whom 10 completed the entire 1-year follow-up duration.