The authors in this study examined the functional mechanisms of anti-CASPR2 aAbs from patients with and without pain on nociceptive neurons and the role of IgG subclasses.
Background and Objectives.
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Gene signature an early warning system for aggressive pancreatic cancer
Precancerous cells must adapt to and overcome cellular stress and inflammation in order to progress and form malignant tumors. Now, researchers have identified a link between stress and inflammation and pancreatic ductal adenocarcinoma (PDAC), one of the most aggressive and lethal types of cancer. The findings could serve as an early warning system for the disease, leading to the detection of PDAC before it becomes life-threatening.
Previous studies have shown that inflammation and cellular stress activate a protein called STAT3 — short for signal transducer and activator of transcription 3 — in pancreas cells, promoting tumor initiation, adaptation to stress and resistance to treatment. How STAT3 accomplishes this has not been understood until now.
In the current study, the researchers discovered that in some cancer cells, STAT3 is able to activate specific genes critical for adaptation to stress and inflammation. They found:
Scientists Find 2 Existing Drugs Can Reverse Alzheimer’s Brain Damage in Mice
In efforts to beat Alzheimer’s disease, researchers are looking at existing drugs that could tackle the condition, and a new study identifies two promising candidates that are currently used to treat cancer.
Already approved by regulators in the US – meaning potential clinical trials for Alzheimer’s could start sooner – the drugs are letrozole (usually used to treat breast cancer) and irinotecan (usually used to treat colon and lung cancer).
Researchers from the University of California, San Francisco (UCSF) and Gladstone Institutes started by looking at how Alzheimer’s altered gene expression in the brain.
AI turns immune cells into precision cancer killers—in just weeks
A breakthrough AI system is revolutionizing cancer immunotherapy by enabling scientists to design protein-based keys that train a patient s immune cells to attack cancer with extreme precision. This method, capable of reducing development time from years to weeks, was successfully tested on known and patient-specific tumor targets. Using virtual safety screenings to avoid harmful side effects, the platform represents a leap forward in personalized medicine.
Brain peptide ODN reduces hunger and boosts glucose regulation in rat study
University of Pennsylvania and Syracuse University scientists have discovered that a hindbrain-derived peptide, octadecaneuropeptide (ODN), can suppress appetite and improve glucose regulation without causing nausea or vomiting. Results suggest a glia-to-neuron signaling axis in the dorsal vagal complex that may be harnessed for treating obesity and type 2 diabetes.
Glial cells in the brainstem produce ODN, a signaling peptide whose physiological role in energy homeostasis has remained obscure. Researchers now find that directly activating this peptide system in the hindbrain induces weight loss, enhances glucose disposal, and lowers insulin resistance in obese animals.
Unlike existing therapies targeting GLP-1 receptors, ODN achieves these effects without triggering nausea-related behaviors or emesis in vomiting-competent models.
Gut microbes could protect us from toxic ‘forever chemicals’
PFAS have been linked with a range of health issues including decreased fertility, developmental delays in children, and a higher risk of certain cancers and cardiovascular diseases.
Scientists at the University of Cambridge have identified a family of bacterial species, found naturally in the human gut, that absorb various PFAS molecules from their surroundings. When nine of these bacterial species were introduced into the guts of mice to ‘humanise’ the mouse microbiome, the bacteria rapidly accumulated PFAS eaten by the mice — which were then excreted in faeces.
The researchers also found that as the mice were exposed to increasing levels of PFAS, the microbes worked harder, consistently removing the same percentage of the toxic chemicals. Within minutes of exposure, the bacterial species tested soaked up between 25% and 74% of the PFAS.
The results are the first evidence that our gut microbiome could play a helpful role in removing toxic PFAS chemicals from our body — although this has not yet been directly tested in humans.
Scientists have discovered that certain species of microbe found in the human gut can absorb PFAS — the toxic and long-lasting ‘forever chemicals.’ They say boosting these species in our gut microbiome could help protect us from the harmful effects of PFAS.