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The latest on nucleotide therapy development

Oligonucleotide therapies — engineered strands of DNA or RNA — are transforming modern medicine. These cutting-edge treatments bring a new level of precision in combating disease by targeting specific genes to be silenced, activated or edited. “Nucleotide therapeutics allow us to design predictable outcomes by modifying sequences to address almost any condition,” says Peter Guterstam, product manager at biotechnology company Cytiva.

Due to an influx of research in recent years, many nucleotide-based drug candidates, including genetic therapies and vaccines for cancer and viral infections, are now in advanced clinical trial stages. “The development timeline is much quicker than we are used to,” notes Guterstam.

Significant challenges arise during development of RNA and DNA based therapies. From mRNA vaccines to gene editing, scientists are refining delivery methods, optimizing synthesis, and tackling scaling hurdles.

GIST Research reveals a promising new target to thwart Alzheimer’s decades before symptoms start

A person will have Alzheimer’s years before ever knowing it. The disorienting erasure of memories, language, thoughts—in essence, all that makes up one’s unique sense of self—is the final act of this enigmatic disease that spends decades disrupting vital processes and dismantling the brain’s delicate structure.

Once symptoms surface and doctors make a diagnosis, though, it can often be too late. Damage is widespread, impossible to reverse. No cure exists.

Attempts to develop drugs that clear away toxic accumulations of amyloid-beta and tau proteins—hallmarks of the disease that cause neurons to die—have ended in hundreds of failed clinical trials. Today, some scientists are skeptical over whether removing amyloid plaques is even enough. Others have a hunch that the best line of attack won’t target just one aspect of the disease, but many of them, all at once.

Hit the wrong spot and an asteroid returns on a collision course

Asteroid deflection could save Earth, or accidentally doom it, depending on where we aim the impact.

Scientists caution that asteroid deflection must be precise, as striking the wrong spot risks sending it through a gravitational keyhole that sets up a future collision with Earth. Using lessons from NASA’s DART mission, researchers are developing probability maps to guide safer impact strategies.

Selecting the right spot to smash a spacecraft into the surface of a hazardous asteroid to deflect it must be done with great care, according to new research presented at the EPSC-DPS2025 Joint Meeting this week in Helsinki. Slamming into its surface indiscriminately runs the risk of knocking the asteroid through a ‘gravitational keyhole’ that sends it back around to hit Earth at a later date.

The hidden meanings of texts and tweets

A ‘spherical’ AI model finds hidden themes in large collections of headlines and other short texts.

From tweets and chat messages to headlines and status updates, short bursts of text are everywhere. These snippets may be brief, but they are packed with the potential to reveal anything from emerging trends to business decisions or circulating misinformation.

While AI is becoming increasingly adept at extracting meaning from long-form text, it still struggles with these bite-sized ones.

Breakthrough 3D Bioprinted Mini Placentas May Help Solve “One Of Medicine’s Great Mysteries”

To address these shortcomings, the team behind the latest study turned to bioprinting – a type of 3D printing that uses living cells and cell-friendly materials to create 3D structures. They took trophoblast cells and mixed them with a synthetic gel before 3D-printing them in precise droplets.

The printed cells then grew into miniature placentas, and the researchers compared them to organoids made via traditional manual methods.

“The organoids we grew in the bioprinted gel developed differently to those grown in an animal-derived gel, and formed different numbers of trophoblast sub-types. This highlighted that the environment organoids are grown in can control how they mature,” first author Dr Claire Richards said.

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