This may be the next big pandemic not for birds but for humans as it has crossed the barrier to affect humans now.
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Protein engineering through the ligation of polypeptide fragments has proven enormously powerful for studying biochemical processes. In general, this strategy necessitates a final protein-folding step, constraining the types of systems amenable to the approach. Here, we report a method that allows internal regions of target proteins to be replaced in a single operation. Conceptually, our system is analogous to a DNA transposition reaction but uses orthogonal pairs of engineered split inteins to mediate the editing process. This “protein transposition” reaction is applied to several systems, including folded protein complexes, allowing the efficient introduction of a variety of noncoded elements. By carrying out a molecular “cut and paste” under native protein-folding conditions, our approach substantially expands the scope of protein semisynthesis.
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A new study published in Nature Communications April 7 could reshape the future of magnetic and electronic technology. Scientists at Rice University have discovered how a disappearing electronic pattern in a quantum material can be revived under specific thermal conditions. The finding opens new doors for customizable quantum materials and in-situ engineering, where devices are manufactured or manipulated directly at their point of use.
Led by Pengcheng Dai, the Sam and Helen Worden Professor of Physics and Astronomy, the researchers uncovered the cause behind a vanishing electronic phenomenon in a class of crystalline materials known as kagome lattice, a geometric arrangement of corner-sharing triangles named after a traditional Japanese basket pattern.
This discovery reveals how heating methods impact the presence of a charge density wave (CDW), a quantum pattern of electron arrangement, in the kagome metal iron germanide (FeGe). It also demonstrates how its reappearance enhances magnetic and electronic properties.
A research team from Helmholtz Munich and the Technical University of Munich has developed an advanced delivery system that transports gene-editing tools based on the CRISPR/Cas9 gene-editing system into living cells with significantly greater efficiency than before. Their technology, ENVLPE, uses engineered non-infectious virus-like particles to precisely correct defective genes—demonstrated successfully in living mouse models that are blind due to a mutation.
This system also holds promise for advancing cancer therapy by enabling precise genetic manipulation of engineered immune cells, making them more universally compatible and thus more accessible for a larger group of cancer patients.
The work is published in the journal Cell.
Recently, a team of researchers from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences (CAS) consecutively removed the innermost atom and the outermost electron of a gold nanoparticle—without disturbing its overall structure. This precise manipulation allowed them to probe how the magnetic spin of the material influences its catalytic activity.
The work, led by Prof. Wu Zhikun in collaboration with Prof. Yang from the Institute of Process Engineering, CAS and Prof. Tang from Chongqing University, was published in Science Advances.
Gold nanoclusters—tiny particles composed of from a few to hundreds of gold atoms —are ideal models for studying how atomic structure affects material properties. But tuning the structure of such clusters atom by atom, especially when they’re relatively large and complex, has long been a major challenge.
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Health care providers can use small devices to hover over moles or lesions and immediately check for common skin cancers, such as melanoma and basal cell carcinoma.
The most significant benefit is that health care professionals who do not specialize in dermatology could perform these checks during a routine visit, making early detection easier and quicker.
Skin cancer is the most common form of cancer in the United States, with one in five Americans expected to be affected in their lifetime, according to the City of Hope Cancer Center.
Without clear protocols to catch errors, artificial intelligence’s growing role in science could do more harm than good.
For generations, sailors around the globe have reported a mysterious phenomenon: Vast areas of the ocean glow steadily at night, sometimes for months on end. The light is bright enough to read by and is oddly similar to the green and white aura cast by glow-in-the-dark stars that have decorated children’s rooms. Stretching over ocean space as broad as 100,000 square kilometers, the light can, at times, even be seen from space.
This rare bioluminescent display was coined by sailors as “milky seas.” Despite being encountered for centuries, scientists still know very little about what causes this glowing effect because they are quite rare—they usually occur in the remote regions of the Indian Ocean, far from human eyes. A likely theory is that the glow comes from activity by a luminous microscopic bacteria called Vibrio harveyi.
To better predict when milky seas will occur, researchers at Colorado State University have compiled a database of sightings over the last 400 years.