Activation of Gs signaling at mitochondria by mitoDREADD-Gs increases mitochondrial metabolism, leading to better memory in mouse models of dementia, directly linking brain mitochondrial deficits to cognitive symptoms of neurodegenerative diseases.
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Using Microbes to Mine the Moon
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Rocky bodies like moons, asteroids, and comets are chock full of resources, from water, to helium-3, to rare earth elements. But how can we access them? Some scientists have proposed using microbes to aid in the mining of certain metals.
Mile-Deep Underwater Volcano Is Inflating ‘Like a Balloon’ and Could Erupt Soon, Scientists Warn
An underwater volcano off the Pacific northwest coast is projected to erupt soon.
Researchers at Oregon State University (OSU) have been recording activity at the Axial Seamount, located roughly 300 miles off the coast of Oregon and 4,900 feet under the surface, per ABC News and Axios. The underwater volcano’s recent behavior has signaled to OSU researchers that it’s tending toward an eruption in the near future.
Digital to analog in one smooth step: Device could replace signal modulators in fiber-optic networks
Addressing a major roadblock in next-generation photonic computing and signal processing systems, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) have created a device that can bridge digital electronic signals and analog light signals in one fluid step.
Built on chips made out of lithium niobate, the workhorse material of optoelectronics, the new device offers a potential replacement for the ubiquitous but energy-intensive digital-to-analog conversion and electro-optic modulation systems used all over today’s high-speed data networks.
“Optical communication and high-performance computing, including large language models, relies on conversion of massive amounts of data between the electrical domain—used for storage and computation—and the optical domain used for data transfer,” said senior author Marko Lončar, the Tiantsai Lin Professor of Electrical Engineering at SEAS.
Rare bone disorder traced to deficiency of an ‘enzyme-rescue metabolite’ in new study
Living cells contain a world of complex parts, which are constantly in motion. Many functions of these parts are still not fully understood, but likely harbor answers to many of our questions about how diseases work and how we might reverse them. One such case has been brought to light.
Enzymes act as catalysts for various processes within cells, but in some cases, they become inactivated by mistakes or environmental factors. When this happens, the processes that the enzymes facilitate may be compromised and lead to disease, depending on what processes are affected.
According to a new study published in Nature, Catel–Manzke syndrome—a bone disorder causing shortened bones, heart defects, cleft palate and finger malformation—may be a result of an inactivated enzyme, called dTDP-D-glucose 4,6-dehydratase (TGDS).
