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Consciousness Is the Only Thing That Truly Exists, Scientist Says

He compares our working minds to a flying kite, where the kite is the brain and the wind is consciousness as a fundamental part of reality. “The kite has to be built from the right materials in the right configuration with the right tether, but its flight depends entirely on the wind,” Reggente says.

A radio makes another good analogy, Reggente explains.

“[The radio] doesn’t produce the broadcast, it receives and transduces a signal that’s already present,” he says. “But unlike a radio, the brain isn’t merely reproducing that signal with high fidelity—it’s interacting with it. And that interaction is what gives rise to our particular subjective experience.”

🚀 The Alien Civilizations That Chose Infinite Knowledge Instead of Space Travel

What if advanced alien civilizations achieved infinite knowledge not through space travel, but by harnessing the power of stars? This video explores how a type 2 civilization could repurpose a star into a giant computer, a concept tied to the kardashev scale and the theoretical dyson sphere. It’s a fascinating look into advanced future technology and the potential of artificial intelligence in the cosmos.

Different Flows of Time All Exist at the Same Moment”: Scientists Claim Trapped-Ion Atomic Clocks Can Observe “Quantum Superposition of Time

Scientists claim they can improve the sensitivity of atomic clocks to measure the quantum superposition of time and possibly explain gravity.

Capsida’s Trailblazing Moment: What the Field Owes the Next BBB Program

An insightful perspective on what biological factors may have been the cause of a patient’s death after receiving a blood-brain-barrier crossing AAV treatment. It’s crucial for the field to think about this carefully as we move forward.

TheBioMLClinic

Brief disclosure: I am a named inventor on patents and author on publications related to AAV capsid engineering and CNS gene delivery, developed during my time at the Broad Institute. I now operate independently. This post does not represent any prior employer, current advisory client, or collaborator. The mechanistic analysis presented here is my own scientific interpretation of publicly available data. Full disclosures at the bottom.

Quantum metasurface boosts terahertz detection sensitivity by exploiting in-plane photoelectric effect

Being able to see light and detect radiation is of utmost importance at any frequency. While this challenge has been solved in the visible range, radiation detectors in the far-infrared and terahertz regimes are either not sensitive, slow, or require bulky and expensive, often cryogenically cooled devices, which hinders practical applications.

A recent study reported in Advanced Photonics combines quantum physics with a carefully designed metasurface to develop a compact detector that improves how THz radiation is captured and converted into an electrical signal.

Preventing uptake of alpha-synuclein to slow Parkinson’s progression

Abstract. Ribosomes are central to protein synthesis in all organisms. In mammals, the ribosome functional core is highly conserved. Remarkably, two rodent species, the naked mole-rat (NMR) and tuco-tuco, display fragmented 28S ribosomal RNA (rRNA), coupled with high translational fidelity and long lifespan. The unusual ribosomal architecture in the NMR and tuco-tuco has been speculated to be linked to high translational fidelity. Here, we show, by single-particle cryo-electron microscopy, that despite the fragmentation of their rRNA, NMR and tuco-tuco ribosomes retain their core functional architecture. Compared to ribosomes of the guinea pig, a phylogenetically related rodent without 28S rRNA fragmentation, ribosomes of NMR and tuco-tuco exhibit poorly resolved density for certain expansion segments. In contrast, the structure of the guinea pig ribosome shows high similarity to the human ribosome. Enhanced translational fidelity in the NMR and tuco-tuco may stem from subtle, allosteric effects in dynamics, linked to rRNA fragmentation.

Neuroscientists discover the brain’s memory center starts “full” and prunes itself down to optimize learning

Far from a blank slate, the infant brain begins with an overabundance of random neural connections. Neuroscientists discovered how trimming this excess wiring transforms the hippocampus into a powerful, structured memory machine.

Mesocorticostriatal Reinforcement Learning of State Representation and Value with Implications for the Mechanisms of Schizophrenia

Mesocorticostriatal dopamine projections are crucial for value learning, motivational control, and cognitive functions. However, while dopamine’s role in value learning as reward-prediction-error (RPE) has been much understood, precise roles in motivational control and cognitive functions remain more elusive. Computationally, this corresponds to that while the operation of mesostriatal dopamine could be minimally described by simple reinforcement learning (RL) models with one-dimensional reward/RPE and fixed state representation, how reward-specific motivational control can be achieved through heterogeneous dopamine responses, and how sophisticated cortical state representation can be formed through mesocortical dopamine, cannot be captured by such simple models.

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