By boosting the activity of cellular ‘power stations’ in the brains of mice with a dementia-like condition, an international team of researchers has reversed pathological memory loss.
Problems with energy-producing cellular structures called mitochondria have previously been linked to neurodegenerative diseases such as Alzheimer’s. Before now, it wasn’t clear if this was a cause or a consequence of these conditions.
“This work is the first to establish a cause-and-effect link between mitochondrial dysfunction and symptoms related to neurodegenerative diseases, suggesting that impaired mitochondrial activity could be at the origin of the onset of neuronal degeneration,” says Giovanni Marsicano, a neuroscientist from the French National Institute of Health and Medical Research (INSERM).
For decades now, the commonly-accepted view among neuroscientists has been that following amputation of a limb, neighboring regions rearrange and essentially take over the area previously assigned to the now missing limb. This has relied on evidence from studies carried out after amputation, without comparing activity in the brain maps beforehand.
To investigate this contradiction, a team of researchers followed three individuals due to undergo amputation of one of their hands. This is the first time a study has looked at the hand and face maps of individuals both before and after amputation.
The researchers examined the signals from the pre-amputation finger maps and compared them against the maps post-amputation. Analysis of the ‘before’ and ‘after’ images revealed a remarkable consistency: even with their hand now missing, the corresponding brain region activated in an almost identical manner.
The study’s senior author, said: Because of our previous work, we suspected that the brain maps would be largely unchanged, but the extent to which the map of the missing limb remained intact was jaw-dropping.
To complement their findings, the researchers compared their case studies to 26 participants who had had upper limbs amputated, on average 23.5 years beforehand. These individuals showed similar brain representations of the hand and lips to those in their three case studies, suggesting long-term evidence for the stability of hand and lip representations despite amputation.
The brain holds a ‘map’ of the body that remains unchanged even after a limb has been amputated, contrary to the prevailing view that it rearranges itself to compensate for the loss, according to new research.
A potential game-changer for fuel cells, smart windows, and next-generation electronics
A team of scientists from Korea and Japan has discovered a new type of crystal that can “breathe”—releasing and absorbing oxygen repeatedly at relatively low temperatures. This unique ability could transform the way we develop clean energy technologies, including fuel cells, energy-saving windows, and smart thermal devices.
China initiated its first multi-center clinical trial for brain-computer interface technology in neurocritical care on Sunday, marking a significant expansion of BCI applications beyond the rehabilitation of motor and cognitive functions.
The trial, launched in Tianjin, aims to explore new therapeutic approaches for severe neurological conditions.
Led by the Haihe Laboratory of Brain-Computer Interaction and Human-Machine Integration at Tianjin University and Tianjin Huanhu Hospital, the project brings together leading medical institutions from Beijing, Tianjin, Henan province, and other regions.
“This initiative will pave the way for broader medical applications, offering Chinese technologies, standards, and protocols for precise management of neurocritical conditions,” said Liu Xiuyun, deputy director of the Haihe Laboratory.
An international team of researchers has announced a significant advancement in gravitational-wave astronomy, with the detection of 128 new cosmic collisions involving black holes and neutron stars.
This discovery more than doubles the number of known gravitational-wave events and marks a major milestone in our understanding of the universe.
The findings come from the latest data release by the Laser Interferometer Gravitational-Wave Observatory (LIGO) Virgo Gravitational Wave Interferometer (Virgo) Kamioka Gravitational Wave Detector (KAGRA) collaboration, a global network of gravitational-wave observatories.
